G Protein-Coupled Receptor--Protein Interactions
Title | G Protein-Coupled Receptor--Protein Interactions PDF eBook |
Author | Susan R. George |
Publisher | Wiley-Liss |
Pages | 362 |
Release | 2005-03-31 |
Genre | Science |
ISBN |
This exciting volume elucidates how GPCRs organize signal transduction and control intracellular activities. Chapters written by the recognized expert in each respective topic offer state-of-the-art updates on the principles and technology, as well as stepwise protocols for methods currently applied to the analysis of protein-receptor interactions.
Receptor-Receptor Interactions
Title | Receptor-Receptor Interactions PDF eBook |
Author | Kjell Fuxe |
Publisher | Springer Science & Business Media |
Pages | 577 |
Release | 2013-03-13 |
Genre | Computers |
ISBN | 1468454153 |
Molecular Aspects of G Protein-coupled Receptors
Title | Molecular Aspects of G Protein-coupled Receptors PDF eBook |
Author | Francisco Ciruela |
Publisher | Nova Publishers |
Pages | 328 |
Release | 2008 |
Genre | Science |
ISBN | 9781600219153 |
In the recent years, studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton. The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.
Neuromorphic Olfaction
Title | Neuromorphic Olfaction PDF eBook |
Author | Krishna C. Persaud |
Publisher | CRC Press |
Pages | 237 |
Release | 2016-04-19 |
Genre | Medical |
ISBN | 1439871728 |
Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
G Protein Signaling
Title | G Protein Signaling PDF eBook |
Author | Alan V. Smrcka |
Publisher | Springer Science & Business Media |
Pages | 246 |
Release | 2008-02-02 |
Genre | Science |
ISBN | 1592594301 |
Alan V. Smrcka presents a collection of cutting-edge methods for investigating G protein signaling from a variety of perspectives ranging from in vitro biochemistry to whole animal studies. Among the readily reproducible techniques presented are those for the purification of G proteins and effectors enzymes, assays of these purified G proteins and effector enzymes, and for the study of G proteins interactions with effectors in intact cells. Additional methods are provided for assaying G protein coupled receptor structure, function, and localization, and for studying the physiological roles for endogenous G proteins.
Determinants of Receptor and G Protein Interactions in G1 and Gq̲-linked Systems
Title | Determinants of Receptor and G Protein Interactions in G1 and Gq̲-linked Systems PDF eBook |
Author | Joseph Bankole Thompson |
Publisher | |
Pages | 380 |
Release | 1997 |
Genre | |
ISBN |
G Protein-Coupled Receptor Screening Assays
Title | G Protein-Coupled Receptor Screening Assays PDF eBook |
Author | Sofia Aires M. Martins |
Publisher | Humana |
Pages | 327 |
Release | 2022-06-19 |
Genre | Science |
ISBN | 9781071612231 |
This fully updated edition targets not only those assays directly involved in the discovery of GPCR-active compounds but also those involved in cell-based experiments designed to study physiological responses. Whether coming from academia or industry, or being an experienced researcher or a newcomer to the field, the reader will find accessible methods and protocols that cover the latest developments on receptor purification, molecular biology, recombinant engineering, and analytical techniques that enable the real time monitoring of the complex GPCR signaling cascade and identification of potential drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, G Protein-Coupled Receptor Screening Assays: Methods and Protocols, Second Edition aims to provide the tools necessary to contribute to the advancement of GPCR research and discovery and ultimately lead to the availability of innovative and more efficient drugs.