Under current NASA plans, investigations in the area of biotechnology will be a significant component of the life sciences research to be conducted on the International Space Station (ISS). They encompass work on cell science and studies of the use of microgravity to grow high-quality protein crystals. Both these subdisciplines are advancing rapidly in terrestrial laboratories, fueled by federal and industrial research budgets that dwarf those of NASA's life science program. Forging strong and fruitful connections between the space investigations and laboratory-bench biologists, a continual challenge for NASA' s life sciences program, is thus of great importance to ensuring the excellence of ISS research. This report evaluates the plan for NASA's biotechnology facility on the ISS and the scientific context that surrounds it, and makes recommendations on how the facility can be made more effective. In addition to questions about optimizing the instrumentation, the report addresses strategies for enhancing the scientific impact and improving the outreach to mainstream terrestrial biology. No major redirection of effort is called for, but collectively the specific, targeted changes recommended by the task group would have a major effect on the conduct of biotechnology research in space.

In response to requests from Congress, NASA asked the National Research Council to undertake a decadal survey of life and physical sciences in microgravity. Developed in consultation with members of the life and physical sciences communities, the guiding principle for the study is to set an agenda for research for the next decade that will allow the use of the space environment to solve complex problems in life and physical sciences so as to deliver both new knowledge and practical benefits for humankind as we become a spacefaring people. The project's statement of task calls for delivery of two books-an interim report and a final survey report. Although the development of specific recommendations is deferred until the final book, this interim report does attempt to identify programmatic needs and issues to guide near-term decisions that are critical to strengthening the organization and management of life and physical sciences research at NASA.

More than four decades have passed since a human first set foot on the Moon. Great strides have been made in our understanding of what is required to support an enduring human presence in space, as evidenced by progressively more advanced orbiting human outposts, culminating in the current International Space Station (ISS). However, of the more than 500 humans who have so far ventured into space, most have gone only as far as near-Earth orbit, and none have traveled beyond the orbit of the Moon. Achieving humans' further progress into the solar system had proved far more difficult than imagined in the heady days of the Apollo missions, but the potential rewards remain substantial. During its more than 50-year history, NASA's success in human space exploration has depended on the agency's ability to effectively address a wide range of biomedical, engineering, physical science, and related obstacles-an achievement made possible by NASA's strong and productive commitments to life and physical sciences research for human space exploration, and by its use of human space exploration infrastructures for scientific discovery. The Committee for the Decadal Survey of Biological and Physical Sciences acknowledges the many achievements of NASA, which are all the more remarkable given budgetary challenges and changing directions within the agency. In the past decade, however, a consequence of those challenges has been a life and physical sciences research program that was dramatically reduced in both scale and scope, with the result that the agency is poorly positioned to take full advantage of the scientific opportunities offered by the now fully equipped and staffed ISS laboratory, or to effectively pursue the scientific research needed to support the development of advanced human exploration capabilities. Although its review has left it deeply concerned about the current state of NASA's life and physical sciences research, the Committee for the Decadal Survey on Biological and Physical Sciences in Space is nevertheless convinced that a focused science and engineering program can achieve successes that will bring the space community, the U.S. public, and policymakers to an understanding that we are ready for the next significant phase of human space exploration. The goal of this report is to lay out steps and develop a forward-looking portfolio of research that will provide the basis for recapturing the excitement and value of human spaceflight-thereby enabling the U.S. space program to deliver on new exploration initiatives that serve the nation, excite the public, and place the United States again at the forefront of space exploration for the global good.

The peaceful use of space flight systems for research and technological devel opments in the context of promoting European and international cooperation represents the essential motivation for the programmes of the European Space Agency (ESA). One of ESA's programmes is dedicated to microgravity research, which is now an established discipline in Europe, with a dedicated group of scientists participating. The Challenger disaster has resulted in a serious dis continuity of flight opportunities in the next few years but the forthcoming International Space Station, new launchers and reentry vehicles are expected to provide ample opportunities for microgravity research in the long term. Meanwhile parabolic aircraft flights, sounding rockets as well as the delayed Shuttle-dependent missions, Spacelab D-2, the IML-missions and EURECA I, will be employed to keep microgravity experimenters reasonably busy in the interim period. To prepare the ground for these activities, both regarding research and experiment facilities, an in-depth analysis of the state of the art is an essential requirement at this time. Such an analysis is presented in this volume. It ad dresses all of the topics that have been identified to be of relevance. Besides a presentation of the fundamental aspects justifying microgravity research, the results of experiments already performed are reviewed and recommendations for future activities are made. Close to fifty European scientists have cooper ated in the preparation of this volume and their dedicated and concerted effort is greatly appreciated.