ABSTRACT Chronic pain is a major health concern in India as well as globally due to increase in prevalence rate of chronic pain in recent years with alarming rate. The aetiology of chronic pain involves biological, psychological, social factors which leads to serious implications in various spheres of life of an individual suffering with chronic pain. Despite of multidimensional nature of chronic pain, the contribution of psychological and social factors in pain management is overlooked and is rarely explored by conducting the empirical research studies. Rheumatoid arthritis is one of the serious causes of chronic pain in the world with higher prevalence rate mainly among women. Rheumatoid arthritis (RA) is an autoimmune disease with unknown causes which is characterized by joint stiffness, severe joint pain. There is no permanent cure for RA at present and is currently managed by mainly using pharmacological treatment. RA has significant impact on an individual's capacity to perform basic daily living activities, professional duties and family responsibilities which ultimately affects mental health of an individual. Depression and anxiety are major mental health concerns among RA patients which are found to be linked with several psychological aspects of an individual. Therefore, considering the role of psychological factors in maintaining wellbeing of an individual with RA, the present research aims to study the effect of pain acceptance and active coping on health-related quality of life and functional status among women with RA. Present study was conducted on the sample of 175 women patients with Rheumatoid Arthritis seeking treatment from two private Rheumatology clinics in Pune. The data for the present study was collected by using purposive sampling method. Mixed method research design was implemented in the present study, wherein first quantitative data was obtained by administering the standardized tools and the qualitative data was collected through in-depth interviews and the participants' responses on open-ended question mentioned in personal information form. The tools for obtaining quantitative data included Chronic Pain Acceptance Questionnaire (CPAQ), Vanderbilt Pain Management Inventory (VPMI), Health Assessment Questionnaire (HAQ) and WHO Quality of life-BREF. Obtained quantitative data was statistically analysed with the help of SPSS Ver.22 by conducting Pearson Product Moment Correlation analysis, ChiSquare test of association and simple linear regression analysis to investigate the relationship between pain acceptance and active coping with health-related quality of

Clinical trials have two purposes -- to treat the patients in the trial, and to obtain information which increases our understanding of the disease and especially how patients respond to treatment. Statistical design provides a means to achieve both these aims, while statistical data analysis provides methods for extracting useful information from the trial data. Recent advances in statistical computing have enabled statisticians to implement very rapidly a broad array of methods which previously were either impractical or impossible. Biostatisticians are now able to provide much greater support to medical researchers working in both clinical and laboratory settings. As our collective toolkit of techniques for analyzing data has grown, it has become increasingly difficult for biostatisticians to keep up with all the developments in our own field. Recent Advances in Clinical Trial Design and Analysis brings together biostatisticians doing cutting-edge research and explains some of the more recent developments in biostatistics to clinicians and scientists who work in clinical trials.

The volume presents a broad spectrum of papers which illustrates a range of current research related to the theory, methods and applications of health related quality of life (HRQoL) as well as the interdisciplinary nature of this work.

A thought-provoking treatise on understanding and treating the aging mind and brain This handbook recognizes the critical issues surrounding mind and brain health by tackling overarching and pragmatic needs so as to better understand these multifaceted issues. This includes summarizing and synthesizing critical evidence, approaches, and strategies from multidisciplinary research—all of which have advanced our understanding of the neural substrates of attention, perception, memory, language, decision-making, motor behavior, social cognition, emotion, and other mental functions. Written by a plethora of health experts from around the world, The Wiley Handbook on the Aging Mind and Brain offers in-depth contributions in 7 sections: Introduction; Methods of Assessment; Brain Functions and Behavior across the Lifespan; Cognition, Behavior and Disease; Optimizing Brain Function in Health and Disease; Forensics, Competence, Legal, Ethics and Policy Issues; and Conclusion and New Directions. Geared toward improving the recognition, diagnosis, and treatment of many brain-based disorders that occur in older adults and that cause disability and death Seeks to advance the care of patients who have perceptual, cognitive, language, memory, emotional, and many other behavioral symptoms associated with these disorders Addresses principles and practice relevant to challenges posed by the US National Academy of Sciences and National Institute of Aging (NIA) Presents materials at a scientific level that is appropriate for a wide variety of providers The Wiley Handbook on the Aging Mind and Brain is an important text for neurologists, psychiatrists, psychologists, physiatrists, geriatricians, nurses, pharmacists, social workers, and other primary caregivers who care for patients in routine and specialty practices as well as students, interns, residents, and fellows.