This book provides guidance regarding the approach to common scenarios encountered in the frozen section laboratory while underscoring diagnostic pitfalls and providing the proper level of diagnostic information to ensure clear communication. Given the use of frozen section in molecular and research pathology, the text also serves as a guide for morphologic examination. Written by experts in the field, the book is organized according to organ system with additional chapters discussing the roles of digital pathology and molecular assays. Each chapter is extensively illustrated to highlight key points that facilitate interpretation and highlight areas for potential error. The goal of this book is to help trainees understand the need for mastery of this unique diagnostic tool, and to aid pathologists who cover frozen section convert practical information provided into diagnostic improvements. Frozen Section Pathology is a comprehensive and state-of-the-art review and serves as a valuable resource for the general surgical pathologist with frozen section responsibilities as well as surgeons who regularly utilize frozen section.

"Intraoperative frozen sections presents diagnostic challenges involved in the evaluation in the pathology lab of specimens obtained during surgery through the case experience of expert pathologists. Sixty three problems cover the wide range of approximately of problems encountered in intraoperative consultations. Each presentation provides the case information as presented to the consultant, the evaluation and analysis of the specimen, discussion of the results and teaching points observed in the case, and an overall comment providing additional context for the diagnostic problem that has been presented. This problem-oriented format makes the book a superb reference resource for the working diagnostician and an ideal teaching tool for the resident or fellow. Coverage includes pediatric specimens and there is a section describing recognition of artifacts. Each case presentation is supported by several high-quality color photomicrographs with detailed explanations of each image, including images of the permanent sections and immunostains where applicable"-- Publisher's description.

A Practical Guide to Frozen Section Technique offers an easy to learn approach to frozen section technique in the form of a highly illustrated handbook intended for onsite use in the laboratory. The book begins with a novel, clearly delineated, step by step approach to learning continuous motion brush technique. Emphasis is placed on recognizing and correcting artifacts during the preparation process. The book addresses all of the steps in the preparation of slides from cutting through cover-slipping. The author’s unique, original techniques for tissue embedding including face down embedding in steel well bars, frozen block cryoembedding and paper cryoembedding are detailed. Variables key to the quality of the preparation including block temperature, tissue properties and section thickness are detailed. The book also covers understanding the cryostat and basic maintenance and care.Sections covering techniques used in Mohs dermatologic surgery, and techniques used in basic animal and human research are discussed by noted experts in their field. A Practical Guide to Frozen Section Technique will be of great value to pathologists, pathology residents in training and also experimental pathology researchers that rely upon this methodology to perform tissue analysis in research.

This new volume of the Biopsy Interpretation Series is a practical, superbly illustrated guide to the technical and interpretive aspects of a frozen section. The focus is on use of the frozen section in intraoperative management of patients, particularly those with tumors. The authors give pathologists a thorough knowledge of the utility and limitations of a frozen section, the appropriate circumstances for doing one, the proper techniques, and the interpretation and reporting of results. The book features more than 300 full-color gross and microscopic images, with discussions of differential diagnosis. A companion Website will provide 300 additional figures, plus a test bank that is ideal for board exam preparation.

The second edition of this well-received book provides detailed information on the basic and advanced laboratory techniques in histopathology and cytology. It offers clear guidance on the principles and techniques of routine and special laboratory techniques. It also covers advanced laboratory techniques such as immunocytochemistry, flow cytometry, liquid-based cytology, polymerase chain reactions, tissue microarray, molecular technology, etc. The book's second edition covers several important recent topics with many new chapters, such as liquid biopsy, artificial neural network, digital pathology, and next-generation sequencing. Each chapter elucidates basic principle, practical methods, troubleshooting, and clinical applications of the technique. It includes multiple colored line drawings, microphotographs, and tables to illustrate each technique. The book is a helpful guide to the post-graduate students and fellows in pathology, practicing pathologists, as well as laboratory technicians, and research students.

Frozen sections are performed while a patient is undergoing surgery as a basis for making an immediate diagnosis that will impact treatment decisions. Frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly for the patient and surgeon. The Frozen Section Library series will provide concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario.

The Second Edition of Biopsy Interpretation: The Frozen Section, a volume in the Biopsy Interpretation Series, addresses the frozen section, which is one of several intraoperative consultative options. It illustrates the practical use of the frozen section in the management of clinical problems, especially tumors. The demands of patient care require knowledge of the assets and limitations of the frozen section, including the practical techniques of its execution, interpretation, and the communication of its results. Although the frozen section is the focus, the central idea behind this book is intraoperative consultation and patient management. This edition features updates to the organ system based chapters as well as a revised chapter on pediatric pathology. Two new chapters on hematopathology and a review of published literature have also been added. The goal of this book is to not only provide updated information on the practice of frozen section, but also to help explain the role the general surgical pathologist can play in the treatment of patients. Features: Histologic illustrations are actual frozen sections, with artifacts Updated and expanded text Emphasis is placed on the morphologic expertise of the surgical pathologist in standard hematoxylin and eosin sections and imprints