This book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. The concluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.

Primary care medicine is the new frontier in medicine. Every nation in the world has recognized the necessity to deliver personal and primary care to its people. This includes first-contact care, care based in a posi tive and caring personal relationship, care by a single healthcare pro vider for the majority of the patient's problems, coordination of all care by the patient's personal provider, advocacy for the patient by the pro vider, the provision of preventive care and psychosocial care, as well as care for episodes of acute and chronic illness. These facets of care work most effectively when they are embedded in a coherent integrated approach. The support for primary care derives from several significant trends. First, technologically based care costs have rocketed beyond reason or availability, occurring in the face of exploding populations and diminish ing real resources in many parts of the world, even in the wealthier nations. Simultaneously, the primary care disciplines-general internal medicine and pediatrics and family medicine-have matured significantly.

In this important new book Gregory E. Pence looks at issues on the frontiers of medicine including gene therapy to produce 'brave new babies', cloning, human eggs and embryos for sale and experiments on human embryos. Pence argues that the conservatism of the medical establishment, the bioethics community, and the public at large has created shibboleths that impede improvements in our quality of life.

In September 1925 the first class of medical students was admitted to the University of Rochester School of Medicine and Dentistry. On January 4, 1926 the Strong Memorial Hospital was officially opened. The first patient was admitted the next day. On January 7th Dr. John J. Morton, Jr., newly appointed Chief of Surgery, performed the first operation. Ten days later the first baby was delivered. From these small beginnings the University of Rochester Medical Center had a steady and strong growth into the internationally renowned center of teaching, research and patient care that it is today. In recognition of its semicentennial the Medical Center con ducted a series of events during the 1975 - 76 year in which medi cal faculty and staff~ alumni, community physicians and distin guished visitors participated. This symposium on "Frontiers of Medicine" was a climactic event of the year's program. The twelve outstanding physicians and scientists undertook to look forward, in selected areas of biological science and medicine, to what promise there may be for developments to come which will significantly affect mankind's health and the quality of life. Four areas were chosen for discussion to cover the span of human life and to include aspects of it which are of vital in terest and in which significant developments now seem to be prob able in the years ahead. So far as possible the presentations sought to cover the basic science, the clinical and the sociologic aspects of each subject area.

New Frontiers in Medical Device Technology offers the engineering, medical, and business communities an up-to-date report on current and emerging medical technologies. This timely and authoritative book brings together a core of experts who provide comprehensive coverage of new medical device technologies and focuses on the link between the engineering and medical aspects. Relevant engineering principles are reviewed before focusing on the state-of-the-art technologies and their applications. For engineers, this book will provide knowledge of the needs, applications, and biological effects of medical devices and thus point the way toward new opportunities for engineering solutions. Members of the medical community will gain an understanding of the engineering concepts applied to medical devices and their most recent applications. Business and legal professionals will acquire a better understanding of medical technology and its enormous market potential.