The report is a survey of theoretical and computational methods in the field of optimal control of distributed parameter systems. This includes systems described by integral equations and partial differential equations. The various studies which have been done are grouped according to the method employed. A number of applications and potential applications of these methods are discussed, and certain deficiencies in the current state of knowledge are noted. Difficulties and opportunities in practical applications are discussed, and suggestions are offered for directions of research to render the results more readily usable. A list of references is included numbering more than 250 items: papers, report, and books.

This volume presents state-of-the-art reports on the theory, and current and future applications of control of distributed parameter systems. The papers cover the progress not only in traditional methodology and pure research in control theory, but also the rapid growth of its importance for different applications. This title will be of interest to researchers working in the areas of mathematics, automatic control, computer science and engineering.

Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.

Many of the most challenging problems in the applied sciences involve non-differentiable structures as well as partial differential operators, thus leading to non-smooth distributed parameter systems. This edited volume aims to establish a theoretical and numerical foundation and develop new algorithmic paradigms for the treatment of non-smooth phenomena and associated parameter influences. Other goals include the realization and further advancement of these concepts in the context of robust and hierarchical optimization, partial differential games, and nonlinear partial differential complementarity problems, as well as their validation in the context of complex applications. Areas for which applications are considered include optimal control of multiphase fluids and of superconductors, image processing, thermoforming, and the formation of rivers and networks. Chapters are written by leading researchers and present results obtained in the first funding phase of the DFG Special Priority Program on Nonsmooth and Complementarity Based Distributed Parameter Systems: Simulation and Hierarchical Optimization that ran from 2016 to 2019.