Bram Stoker Best Novel Award Finalist and International Horror Guild Best Novel Award Winner Two couples, both skeptical and desperate, are drawn together by a medium named Oona, a fragile, beautiful young woman who knows things that no other living person should know. Is her gift real, or is it the sign of a consuming madness? Can she lead them all to important truths, or will they be trapped in the tightening web of terror and death?

From the author-illustrator of The Book of Mistakes comes a gorgeous picture book about caring for your own heart and living with kindness and empathy. My heart is a window. My heart is a slide. My heart can be closed...or opened up wide. Some days your heart is a puddle or a fence to keep the world out. But some days it is wide open to the love that surrounds you. With lyrical text and breathtaking art, My Heart empowers all readers to listen to the guide within in this ode to love and self-acceptance.

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.

A clever and whimsical environmental fable about a bird who is a human-watcher from a dynamic author-illustrator duo. Warble is a small yellow warbler who lives on the beautiful island of Icyland, where he pursues his hobby of human watching. But on a warm day, a deep fog rolls in and obscures his view. The rest of the birds don't seem to notice the fog or the other changes Warble observes on the island. The more the fog is ignored, the more it spreads. When a Red-hooded Spectacled Female (Juvenile) appears, Warble discovers that he's not the only one who notices the fog. Will they be able to find others who can see it too? And is the fog here to stay? Kyo Maclear's witty story, brought to life with the delicate, misty artwork of Kenard Pak, is a poignant yet humorous reminder of the importance of environmental awareness.

A comprehensive guide to Fog and Edge applications, architectures, and technologies Recent years have seen the explosive growth of the Internet of Things (IoT): the internet-connected network of devices that includes everything from personal electronics and home appliances to automobiles and industrial machinery. Responding to the ever-increasing bandwidth demands of the IoT, Fog and Edge computing concepts have developed to collect, analyze, and process data more efficiently than traditional cloud architecture. Fog and Edge Computing: Principles and Paradigms provides a comprehensive overview of the state-of-the-art applications and architectures driving this dynamic field of computing while highlighting potential research directions and emerging technologies. Exploring topics such as developing scalable architectures, moving from closed systems to open systems, and ethical issues rising from data sensing, this timely book addresses both the challenges and opportunities that Fog and Edge computing presents. Contributions from leading IoT experts discuss federating Edge resources, middleware design issues, data management and predictive analysis, smart transportation and surveillance applications, and more. A coordinated and integrated presentation of topics helps readers gain thorough knowledge of the foundations, applications, and issues that are central to Fog and Edge computing. This valuable resource: Provides insights on transitioning from current Cloud-centric and 4G/5G wireless environments to Fog Computing Examines methods to optimize virtualized, pooled, and shared resources Identifies potential technical challenges and offers suggestions for possible solutions Discusses major components of Fog and Edge computing architectures such as middleware, interaction protocols, and autonomic management Includes access to a website portal for advanced online resources Fog and Edge Computing: Principles and Paradigms is an essential source of up-to-date information for systems architects, developers, researchers, and advanced undergraduate and graduate students in fields of computer science and engineering.

This book provides an analysis of the role of fog computing, cloud computing, and Internet of Things in providing uninterrupted context-aware services as they relate to Healthcare 4.0. The book considers a three-layer patient-driven healthcare architecture for real-time data collection, processing, and transmission. It gives insight to the readers for the applicability of fog devices and gateways in Healthcare 4.0 environments for current and future applications. It also considers aspects required to manage the complexity of fog computing for Healthcare 4.0 and also develops a comprehensive taxonomy.