In a 1984 interview with longtime friend Edna O’Brien, Philip Roth describes her writing as "a piece of fine meshwork, a net of perfectly observed sensuous details that enables you to contain all the longing and pain and remorse that surge through the fiction." The phrase "fine meshwork" can apply not only to O’Brien’s writing but also to the connective threads that bind her work to others’, including, most illuminatingly, Roth’s. Since the publication of their first controversial novels in the 1950s and 1960s, Roth and O’Brien have always argued against the isolation of mind from body, autobiography from fiction, life from art, and self from nation. In Fine Meshwork, Dan O’Brien investigates the shared concerns of these two authors, now regarded as literary icons in their home countries. He traces their fifty-year literary friendship and the striking parallels in their books and reception, bringing together what, at first glance, seem to be quite disparate milieus: the largely feminist and Irish scholarship on O’Brien with Jewish and American perspectives on Roth. In doing so, and in considering them in a transnational context, he argues that the intertwined nature of their writing symbolizes the far-ranging symbiosis between Irish literature and its American—particularly Jewish American—counterpart.

This book presents recent topics on the development, differentiation, and myelination of Schwann cells, as well as pathological mechanisms and therapeutic approaches for peripheral neuropathies, such as Charcot–Marie–Tooth diseases, amyloid polyneuropathy, immune-mediated neuropathy and diabetic neuropathy. The rapid progress of molecular biological techniques in the last decades, especially for RNA techniques and gene modification technologies have allowed us to investigate the pathobiology of Schwann cells in vivo and in vitro. Studies combining recent stem cell biology with recent biotechnology, which is now closely linked to physicochemical fields, further explain how Schwann cell lineages develop a process that has long been thought to be very complicated in vivo. The findings contribute to the elucidation of fundamental mechanisms during development and under pathological conditions. We now know that these are closely tied to each other. This book also introduces unique coculture systems to reproduce the neuron–Schwann cell interplay during development, degeneration, and regeneration. Up-to-date research topics with high-quality immunofluorescence and electron micrographs introduced by young and energetic contributors are sure to arouse the readers' interest in Schwann cell biology. Discussion from the viewpoint of basic and clinical neuroscience makes the book educational for researchers, medical students and young clinicians.

This volume in the Illustrated Colour Text series brings together high quality illustrations and a concise text focussed on essential features and is ideal for modern, medical undergraduate curricula where basic sciences emphasise the principle points of relevance to the students. Volume in Illustrated Colour Text series. Same first author as Embryology volume. Clinically relevant overview ideal for medical and other health science students. Extensively illustrated with both colour photomicrographs and line drawings.