The sector of fine chemicals, including pharmaceuticals, agrochemicals, dyes and pigments, fragrances and flavours, intermediates, and performance chemicals is growing fast. For obvious reasons chemistry is a key to the success in developing new processes for fine chemicals. However, as a rule, chemists formulate results of their work as recipes, which usually lack important information for process development. Fine Chemicals Manufacture, Technology and Engineering is intended to show what is needed to make the recipe more useful for process development purposes and to transform the recipe into an industrial process that will be safe, environmentally friendly, and profitable.The goal of this book is to form a bridge between chemists and specialists of all other branches involved in the scale-up of new processes or modification of existing processes with both a minimum effort and risk and maximum profit when commercializing the process. New techniques for scale-up and optimization of existing processes and improvements in the utilization of process equipment that have been developed in recent years are presented in the book.

This book is a comprehensive reference on one of the most exciting and challenging segments of the modern chemical industry. It comprises descriptions of the leading fine chemical companies, the products, markets and technologies on a global basis. It serves also as a guide for developing and succeeding in the $60 billion fine chemicals business, which is usually lumped into the chemical or pharmaceutical industry.

The sector of fine chemicals, including pharmaceuticals, agrochemicals, dyes and pigments, fragrances and flavours, intermediates, and performance chemicals is growing fast. For obvious reasons chemistry is a key to the success in developing new processes for fine chemicals. However, as a rule, chemists formulate results of their work as recipes, which usually lack important information for process development. Fine Chemicals Manufacture, Technology and Engineering is intended to show what is needed to make the recipe more useful for process development purposes and to transform the recipe into an industrial process that will be safe, environmentally friendly, and profitable.The goal of this book is to form a bridge between chemists and specialists of all other branches involved in the scale-up of new processes or modification of existing processes with both a minimum effort and risk and maximum profit when commercializing the process. New techniques for scale-up and optimization of existing processes and improvements in the utilization of process equipment that have been developed in recent years are presented in the book.

The book gives a complete overview on today's research, development and industrialization of fine chemicals from acetylene. The author provides a comprehensive methodology by covering derivatives from acetylene reacting with formaldehyde, alcohol, ketone, halogen and acetic acid. The book offers extensive and practical reference work for chemists and chemical engineers as well as university teachers and students.

Table 1 E factors (tonnes of waste generated per tonne of product manufactured [7] Industry segment Annual product tonnage E factor 6 8 Oil refining 10 –10 Approx. 0. 1 4 6 Bulk chemicals 10 –10

In modern age chemical industries have permeated most extensively in comparison with other industries and are progressing at a very rapid pace. Chemical Industry in India is one of the fastest growing industries under the Indian economy. The chemical industry comprises the companies that produce industrial chemicals. Central to the modern world economy, it converts raw materials into more than 70,000 different products. Chemicals have contributed in various sectors like food industry, fertilizers, perfumery, fragrance and flavour etc. Chemicals are used to make a wide variety of consumer goods, as well as thousands inputs to agriculture, manufacturing, construction, and service industries. There are numerous chemicals produced in chemical industry for example chloroform, caffeine, fertilizers , dyes, drug intermediates, herbicide, inorganic salts, copper sulphate, acetaldehyde etc. The chemical industry itself consumes 26 percent of its own output. The Chemical Industry in India is based on the idea of diversification. For example inorganic chemicals is the sector where the growth rate is near about 9% and the chemicals produced in this sector are mainly used in alkalis, fertilizers, etc. Depending on the product categories the chemical industry is divided in many other sectors like drugs and pharmaceuticals, fertilizers, fine chemicals like dyes and paints etc. The chemical industry in India which generates almost 13% of total national export is growing annually at a growth rate anywhere between 10% and 12%. This book majorly deals with the molecular formula, raw materials, properties, laboratory testing, manufacturing process explained with flow diagrams and uses of the chemicals. The major contents of the book are inorganic salts, inorganic chemicals, industrial gas, fertilizers, alum, caffeine, ceramic chemicals etc. This book covers the production of more than 100 chemicals for example acetanilide, methylamine, butylamine, linalol, phosphorous, salicylic acid etc. This book should be of great value to young chemical engineers and chemists who are just entering the field but those already practicing will find much of interest and use for broadening of their insight in to fields in which they are only marginally informed. It is hoped that this book will aid to young engineers, chemical, civil, mechanical and electrical as well as chemists, in understanding the value of chemical, the type of problems met in their production and method for solving these problems. 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The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.