LOS ANGELES TIMES AND PUBLISHERS WEEKLY BESTSELLER • The powerful memoir of a young doctor and former college athlete diagnosed with a rare disease who spearheaded the search for a cure—and became a champion for a new approach to medical research. “A wonderful and moving chronicle of a doctor’s relentless pursuit, this book serves both patients and physicians in demystifying the science that lies behind medicine.”—Siddhartha Mukherjee, New York Times bestselling author of The Emperor of All Maladies and The Gene David Fajgenbaum, a former Georgetown quarterback, was nicknamed the Beast in medical school, where he was also known for his unmatched mental stamina. But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime. Miraculously, Fajgenbaum survived—only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself. More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide. Praise for Chasing My Cure “A page-turning chronicle of living, nearly dying, and discovering what it really means to be invincible in hope.”—Angela Duckworth, #1 New York Times bestselling author of Grit “[A] remarkable memoir . . . Fajgenbaum writes lucidly and movingly . . . Fajgenbaum’s stirring account of his illness will inspire readers.”—Publishers Weekly

A timely, authoritative, and entertaining history of medicine in America by an eminent physician Despite all that has been written and said about American medicine, narrative accounts of its history are uncommon. Until Ira Rutkow’s Seeking the Cure, there have been no modern works, either for the lay reader or the physician, that convey the extraordinary story of medicine in the United States. Yet for more than three centuries, the flowering of medicine—its triumphal progress from ignorance to science—has proven crucial to Americans’ under-standing of their country and themselves. Seeking the Cure tells the tale of American medicine with a series of little-known anecdotes that bring to life the grand and unceasing struggle by physicians to shed unsound, if venerated, beliefs and practices and adopt new medicines and treatments, often in the face of controversy and scorn. Rutkow expertly weaves the stories of individual doctors—what they believed and how they practiced—with the economic, political, and social issues facing the nation. Among the book’s many historical personages are Cotton Mather, Benjamin Franklin, George Washington (whose timely adoption of a controversial medical practice probably saved the Continental Army), Benjamin Rush, James Garfield (who was killed by his doctors, not by an assassin’s bullet), and Joseph Lister. The book touches such diverse topics as smallpox and the Revolutionary War, the establishment of the first medical schools, medicine during the Civil War, railroad medicine and the beginnings of specialization, the rise of the medical-industrial complex, and the thrilling yet costly advent of modern disease-curing technologies utterly unimaginable a generation ago, such as gene therapies, body scanners, and robotic surgeries. In our time of spirited national debate over the future of American health care amid a seemingly infinite flow of new medical discoveries and pharmaceutical products, Rutkow’s account provides readers with an essential historic, social, and even philosophical context. Working in the grand American literary tradition established by such eminent writer-doctors as Oliver Wendell Holmes, William Carlos Williams, Sherwin Nuland, and Oliver Sacks, he combines the historian’s perspective with the physician’s seasoned expertise. Capacious, learned, and gracefully told, Seeking the Cure will satisfy armchair historians and doctors alike, for, as Rutkow shows, the history of American medicine is a portrait of America itself.

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century. Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research. Scientists such as Stockwell are now developing methods to combat these complexities technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

A rigorous, sceptical, deeply reported look at the new science behind the mind's extraordinary ability to heal the body. Have you ever felt a surge of adrenaline after narrowly avoiding an accident? Salivated at the sight (or thought) of a sour lemon? Felt turned on just from hearing your partner's voice? If so, then you've experienced how dramatically the workings of your mind can affect your body. Yet while we accept that stress or anxiety can damage our health, the idea of 'healing thoughts' was long ago hijacked by New Age gurus and spiritual healers. Recently, however, serious scientists from a range of fields have been uncovering evidence that our thoughts, emotions, and beliefs can ease pain, heal wounds, fend off infection and heart disease, even slow the progression of AIDS and some cancers. In Cure, award-winning science writer Jo Marchant travels the world to meet the physicians, patients and researchers on the cutting edge of this new world of medicine. We learn how meditation protects against depression and dementia, how social connections increase life expectancy, and how patients who feel cared for recover from surgery faster. We meet Iraq war veterans who are using a virtual arctic world to treat their burns and children whose ADHD is kept under control with half the normal dose of medication. We watch as a transplant patient uses the smell of lavender to calm his hostile immune system and an Olympic runner shaves vital seconds off his time through mind-power alone. Drawing on the very latest research, Marchant explores the vast potential of the mind's ability to heal, acknowledges its limitations, and explains how we can make use of the findings in our own lives. ‘A thought-provoking exploration of how the mind affects the body and can be harnessed to help treat physical illness, by an award-winning science journalist.’ Best Books of 2016, Australian Financial Review ‘A thought-provoking exploration.’ Best Books of 2016, Economist

"A guide intended to help readers become less lonely"--

After an experiment-gone-wrong causes him to turn into a huge green monster when he is angry, Bruce Banner searches for a cure while the army seeks him out to use as a weapon.

2024 Garden State Children's Book Award Nominee 2023 Finalist AAAS/Subaru SB&F Prize for Excellence in Science Books Tu Youyou's malaria treatment saved millions of lives, and she became the first Chinese woman to win a Nobel Prize. Tu Youyou had been interested in science and medicine since she was a child, so when malaria started infecting people all over the world in 1969, she went to work finding a treatment. Trained as a medical researcher in college and healed by traditional medicine techniques when she was young, Tu Youyou started experimenting with natural Chinese remedies. The treatment she discovered through years of research and experimentation is still used all over the world today.