This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn’s disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe.

This book conjoins the latest advances on the use of endoscopy to diagnose, monitor, and treat patients with inflammatory bowel disease. Chapters include the historical use of rigid sigmoidoscopy, non-interventional imaging procedures, and the correlation of pathology and endoscopic visualization. This is the first book to include individual chapters in gastroenterology, colorectal surgery, and IBD texts, the preeminent role of endoscopic imaging in the management of chronic ulcerative colitis, and Crohn's disease. It also includes chapters on capsule endoscopy and balloon and overtube-assisted enteroscopy to define the presence and activity of Crohn's enteritis and additional chapters defining the use of random biopsies versus chromoendoscopy, and computer enhanced imaging to define possible dysplasia development. The book also includes access to online videos, making it the ultimate verbal and visual tool for all medical professionals interested in the advances in the field over the last several decades. Endoscopy in Inflammatory Bowel Disease is a concise text that is of great value to practicing endoscopists, gastroenterologists, general or colorectal surgeons, physicians in training, and all medical professionals caring for patients with inflammatory bowel disease.

This comprehensive atlas, containing a wealth of high-quality images, illustrates the complete spectrum of presentations of inflammatory bowel diseases (IBD). It focuses especially on the most recent developments in the use of endoscopy in IBD, providing detailed guidance on endoscopic indices of disease activity, diagnosis, and differential diagnosis. In addition to ileocolonoscopy, small bowel endoscopy, and esophagogastroduodenoscopy, chapters are included on the role of both established radiological techniques, such as CT, MRI, and abdominal ultrasonography, and the newest approaches, including high-resolution endoscopy, narrow band imaging, and confocal laser endomicroscopy. Extraintestinal manifestations and complications are addressed in separate chapters, and the book concludes by presenting surgical findings. The authors are international authorities with diverse expert knowledge who have collaborated to create an ideal tool for all who wish to master endoscopic evaluation in IBD.

Inflammatory Bowel Disease: From Bench to Bedside is a detailed and comprehensive story of the local and systemic pathophysiology of intestinal inflammation including management strategies. Research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders is explored. This volume blends recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease and emphasizes the effectiveness of a team approach of basic scientists and clinician investigators in this field.

Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn’s Disease and Ulcerative Colitis Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn’s Disease and Ulcerative Colitis Contains access to videos demonstrating important procedural concepts

Grouping ulcerative colitis with Crohn's disease (Inflammatory Bowel Disease) in a teaching seminar has historical support. The medical literature includes descriptions of both diseases in the latter half of the 19th century; they share many symptoms; in some instances, differentiating them may be very difficult; and the cause of each remains unknown. Furthermore, one member of a family may suffer with Crohn's disease while another has ulcerative colitis. And both processes are prone to the late complications of carcinoma at a site of previous involvement. Finally, the investigators and students of one disease have usually also contributed to the understanding of the other disease. The incidence of Crohn's disease seems to be increasing rapidly. This has been sug gested by reports from Sweden, the Netherlands, England, Scotland, and South Africa as well as the United States. Though methods of recording data vary, the increase is further supported by cases of greater virulence, still younger ages of onset, and more cases in the elderly. This is remarkable when we consider that fifty years ago, when the classic description from Mt. Sinai Hospital was being prepared, the disease was rare. Since the cause remains elusive, we must try to cope with this entity as skillfully as we can, with consideration of indications, and timing of drug and surgical intervention. The choice of forms of management has been controversial, even among the most experi enced physicians.