Hulk, Dr. Strange, Sub-Mariner, Valkyrie and Nighthawk join up with Luke Cage, Daredevil and Son of Satan to take on the likes of the Wrecking Crew, Satannish and Asmodeus. Then, spinning out of a storyline in Marvel Two-In-One, comes Steve Gerber! Deconstructing genre conventions and adding a healthy dose of absurdity, Gerber's innovative run turned the expectations of readers on their heads, so suitably we're including the original Atlas Era appearances of the Headmen-Gorilla Man, Jerold Morgan and Chondu the Mystic! COLLECTING: DEFENDERS 17-21, GIANT-SIZE DEFENDERS 2-4, MARVEL TWO-IN-ONE 6-7

Collects Fantastic Four (2018) #12-13, Fantastic Four: 4 Yancy Street (2019) #1, Fantastic Four: Negative Zone (2019) #1. One of the biggest FF secrets of all time is finally revealed — and the fallout will be huge! First, newlyweds Ben Grimm and Alicia Masters are off on their dream honeymoon at last! It’s a remote tropical paradise — until someone decides to crash it. Or should we say - smash it?! It’s ever-lovin’ against ever-livin’ as the Thing battles the Immortal Hulk! Then, one of Reed Richards’ biggest regrets leads to a voyage to the one place in the universe the Fantastic Four have never been. But awaiting them there are the heroic Unparalleled — whose destiny is to repel the fearsome FF! Who is the winged warrior named Sky? What is her shocking connection to the Human Torch’s origin? And how will she change his life forever? Punches will be thrown and lives will be altered!

Two Inhuman children seek refuge with the Fantastic Four, threatening to cause an inter-species war. Reed forgets their anniversary (again!) so Alicia, Crystal, and the She-Hulk take Susan out for a night on the town. Someone is attacking the tough guys of Yancy Street and Ben Urich, Jessica Jones, and the Thing are on the case. And finally, the reality-bending Impossible Man pops up again.

Lee and Kirby spin the classics with characters and concepts that remain among Marvel's mainstays today! After being lorded over in Latveria by Doctor Doom, the FF face a new level of grudge match when the Thing is tapped for the fighting arena of gangster Skrulls! Featuring the enigmatic inhumans, the Frightful Four, the Mad Thinker and other enduring opponents! Guest-starring Magneto and the Sub-Mariner! Plus: classic invasions from under the earth and under the sea! COLLECTING: FANTASTIC FOUR (1961) 84-110, ANNUAL 7-8

Inside a room kept secret from even his closest friends and family, Reed Richards had scrawled upon the walls 100 of the biggest and boldest ideas his brain could produce. And, recently, he added a 101st, the most audacious ever: "Solve everything." It would be a mantra that would lead the obsessively intellectual Mr. Fantastic to doing great works on behalf of humanity - and, in typically fantastic fashion, lead him into even greater trouble! For, as the big brain of the Fantastic Four will find out, solving everything carries with it a great cost, and one that is perhaps too much to pay.

"Contains material originally published in magazine form as Fantastic Four # 575-578"--Indicia.

Celebrate 60 years of the World's Greatest Comics Collaboration! Stan Lee and Jack Kirby conclude their record-setting tenures on the FANTASTIC FOUR, the book that birthed the Marvel Universe! In Kirby's final issues, Doctor Doom lurks in the shadows, the FF save Apollo 11 from an alien threat, and the Sub-Mariner and Magneto team up to attack our heroes! Then, Stan Lee is joined by Marvel art legends John Romita Sr. and John Buscema to forge a new future for Marvel's first family! Along the way, the Thing battles the Hulk, the Surfer is taken captive by Galactus, and the Overmind menaces Earth -- leading to the strangest event in Marvel history: Doctor Doom joins the FF?! Guest-starring Black Panther, the Inhumans and more! COLLECTING: Fantastic Four (1961) 94-125, Fantastic Four: The Lost Adventure (2008) 1, material from Fantastic Four Annual (1963) 8-9