Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Gnosis means knowledge. But we are not referring to just any knowledge. Gnosis is knowledge which produces a great transformation in those who receive it. Knowledge capable of nothing less than waking up man and helping him to escape from the prison in which he finds himself. That is why Gnosis has been so persecuted throughout the course of history, because it is knowledge considered dangerous for the religious and political authorities who govern mankind from the shadows. Every time this religion, absolutely different from the rest, appears before man, the other religions unite to try to destroy or hide it again. Primordial Gnosis is the original Gnosis, true Gnosis, eternal Gnosis, Gnostic knowledge in its pure form. Due to multiple persecutions, Primordial Gnosis has been fragmented, distorted and hidden.

Report and compilation of statistical tables resulting from a survey of the handicapped (disabled person), undertaken in 1966 by the social security administration, on demographic aspects and health-related characteristics of handicapped widowed married women in the USA, together with information on their eligibility to receive disability benefits.