Embark on a transformative journey into the realm of regenerative medicine with our groundbreaking publication, "Exosomal Elixir." This pivotal book serves as a comprehensive guide for anyone captivated by the potential of Mesenchymal Stem Cell (MSC)-derived exosomes in therapeutic applications. Delve into the intricate world of Mesenchymal Stem Cells and their remarkable ability to give rise to exosomes - tiny yet powerful agents of healing and regeneration. "Exosomal Elixir" isn't just a window into advanced scientific research; it's a gateway to understanding how these microscopic marvels are revolutionizing the field of cellular healing. Witness the emergence of exosome research as a game-changer in biomedical innovations. Learn about the synergistic relationship between MSCs and their derived exosomes, which collectively open new frontiers in treating and healing various medical conditions. Ideal for healthcare professionals, biologists, and anyone intrigued by the cutting-edge of medical science, this book is your key to comprehending the remarkable capabilities of therapeutic exosomes. "Exosomal Elixir" is more than just a book; it's a beacon of knowledge in the pursuit of understanding and harnessing the healing powers of stem cell therapy and exosome research. Secure your copy today and be a part of this exciting journey into the future of regenerative medicine!

This proceedings volume results from the NATO Advanced Research Workshop on 'Biomarkers of Radiation in the Environment: Robust Tools for Risk Assessment (BRITE)’. The BRITE workshop discussed insights from cancer research, epigenetics, non-human and human risk assessment, since many of the state-of-the-art biomarkers being developed for humans deserve consideration for environmental applications and vice versa. Sessions were very wide-ranging covering methods, mechanisms, cross disciplinary application and regulation. The chapters in this book have been grouped into five major themes that were covered by the BRITE workshop: · Techniques for biomarker development · Low-dose effect mechanisms · Biomarkers for risk evaluation · Biomarkers in wildlife · Biomarker use and responses Each chapter has been written independently and reflects the views of the chapter author(s). Therefore, the readers can form their own balanced view of the different perspectives on biomarkers of radiation in the environment. Given the breadth of topics covered and the state-of-the-art perspectives shared by leading experts in their respective fields, this book should form a valuable resource for anyone with an interest in how biomarkers can be used to improve our understanding of radiation in the environment and its potential impacts.

Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

In May 2020, the publication of a scientific paper on the rejuvenation of rats shook the foundations of the community that studies the possibility of undoing aging. An average epigenetic rejuvenation of 54% of the animals was reported in the article, in addition to the reversal of dozens of biochemical markers of old rats to values typical of young rats. The main developer of the treatment that led to these results was Dr. Harold Katcher, author of The Illusion of Knowledge. The reception of the specialized scientific community to the experiment was shock, with the phrase "it's too good to be true" repeated almost instinctively. Thus, Dr. Katcher decided to write this book, explaining in detail the foundations of his theory of aging and the evolutionary and biochemical bases of the mechanisms that determine the lifespan of different species. However, in this book, Dr. Katcher has done much more than address the strictly scientific part. By also conducting an in-depth analysis of the history of scientific ideas and humanity's relationship with the idea of immortality, he shows that it is no accident that he may have made the greatest discovery in human history.

This handbook is the next volume in the series of the scientific and educational publications of the European Society of Preventive, Regenerative and Anti-Aging Medicine. To promote the development of the science and practice of anti-ageing and active longevity, ESAAM has published in 2023 the Handbook of Anti-Aging Medicine. This cornerstone book was devoted to main theoretical issues in combating the mechanisms of aging. Current handbook provides the basics of practical life extension protocols. Leading specialists in regenerative and longevity medicine presented their valuable recommendations. Special attention is paid to the fundamental principles of the longevity clinic, as well as practical instructions on which of the existing protocols are the most effective from the point of view of international experts. Their experience is described in 13 chapters and covers the next fields of the longevity medicine: • Immune ageing • Hormetic nutrients • Measurements of aging • Policies for healthy longevity • The fundamentals of Mayr medicine in longevity • How sexuality and eroticism promote healthy ageing • Protocols of regeneration technologies for the longevity medicine • Holistic approaches to healthy longevity • International collaboration in longevity • Cell and molecular therapies This book is highly recommended for all physicians working with ageing patients and persons having disorders promoting premature and accelerated ageing. Also, practical focus makes this book essential for managers and specialists of the preventive, anti-aging and longevity medicine.

This Research Topic celebrates the 50th anniversary of the first heart transplant performed in December of 1967 in Cape Town, South Africa. Cardiovascular researchers met in South Africa in December 2017 to commemorate this event, presenting an opportune time to reflect on the achievements of applied cardiovascular research and highlight forthcoming technology developments that will shape the future of cardiovascular medicine. The clinical breakthrough in 1967 offered hope to many patients suffering with cardiac complications, and these life-saving surgeries continue to have a tremendous impact. Tissue shortages, surgical risks, and complications due to improper host-transplant tissue interactions, however, limit the utility of heart transplants to the most severe cases of cardiac morbidity. Recent advances have yielded mechanistic insight into the factors that control cardiovascular tissue maintenance and remodeling. The field of regenerative medicine seeks to control these factors to promote in situ tissue regeneration or engineered tissue replacement. These exciting new technologies could lead to a renaissance in the treatment of many cardiovascular diseases, just as the realization of heart transplantation 50 years ago. In this Research Topic, researchers and clinicians from regenerative medicine and applied cardiovascular biology provide literature reviews and original manuscripts to demonstrate the trajectory of cardiovascular medicine. The contributions vertically integrate advances by clinicians, engineers, and basic scientists, all researching similar topics from different angles and with complementary perspectives. Taken together, these contributions demonstrate the process of applied cardiovascular research from basic science discoveries to implementation in clinical practice.