Evolution's Clinical Guidebook: Translating Ancient Genes into Precision Medicine demonstrates, through well-documented examples, how an understanding of the phylogenetic ancestry of humans allows us to make sense out of the flood of genetic data streaming from modern laboratories and how it can lead us to new ways to prevent, diagnose and treat diseases. Topics cover evolution and human genome, meiosis and other recombinants events, embryology, speciation, phylogeny, rare and common diseases, and the evolution of aging. This book is a valuable source for bioinformaticians and those in the biomedical field who need knowledge, down to gene level, to fully comprehend currently available data. Offers an innovative approach, focusing on how disease-associated pathways evolved Explains how the fields of phylogeny and embryology have become closely tied to the fields of genetics and bioinformatics Demonstrates how students and biomedical professionals can apply the knowledge obtained in this book to the theory and practice of precision medicine

Medicine is grounded in the natural sciences, among which biology stands out with regard to the understanding of human physiology and conditions that cause dysfunction. Ironically though, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunology, including adaptations to dietary innovations, as well as adaptations to the exposure to novel pathogens. Rapid pathogen evolution and evolution of cancer cells cause major problems for the immune system to find adequate responses. In addition, many adaptations to past ecologies have turned into risk factors for somatic disease and psychological disorder in our modern worlds (i.e. mismatch), among which epidemics of autoimmune diseases, cardiovascular diseases, diabetes and obesity, as well as several forms of cancer stand out. In addition, depression, anxiety and other psychiatric conditions add to the list. The Oxford Handbook of Evolutionary Medicine is a compilation of cutting edge insights into the evolutionary history of ourselves as a species, and how and why our evolved design may convey vulnerability to disease. Written in a classic textbook style emphasising physiology and pathophysiology of all major organ systems, the Oxford Handbook of Evolutionary Medicine will be valuable for students as well as scholars in the fields of medicine, biology, anthropology and psychology.

Although there are several books on the phylogenetic relationships of animals, this is the first to focus on the consequences of such relationships for the evolution of organs themselves. It provides a summary of evolutionary hypotheses for each of the major organ systems, describing alternative theories in those cases of continuing controversy.

Provocative, science-based, and practical, "Evolution Rx" presents a new and powerful way of understanding the human body based on evolutionary medicine.

Offers the very latest on the theory and practice of integrating mini-implant techniques into clinical practice This all-new second edition of The Orthodontic Mini-implant Clinical Handbook provides a thoroughly revised and expanded update to the theoretical and practical aspects of using mini-implants in orthodontic practice. Taking a practical step-by-step approach with hundreds of clinical images, it presents updated clinical techniques and new clinical cases, covering all topics of importance for utilising mini-implants. It also includes a new chapter on mini-implant anchored maxillary expansion appliances. It begins with a chapter that looks at mini-implant principles and potential complications, before moving onto clinical and design factors for maximising mini-implant success. Other chapters cover incisor retraction; molar distalisation and protraction; intrusion and anterior openbite treatments; bone anchored rapid maxillary expansion; orthognathic surgical uses; and ectopic teeth. Provides a comprehensive guide to both theoretical and practical advice for the use of mini-implants in orthodontic practice Covers updated clinical techniques and new clinical cases Presents a new chapter on mini-implant anchored maxillary expansion appliances Takes a highly illustrated step-by-step approach ideal for clinical practice The Orthodontic Mini-Implant Clinical Handbook is an essential resource to orthodontists, maxillofacial surgeons, practicing dentists, and anyone with an interest in mini-implant skeletal anchorage.

Condensing the most important topics in all of clinical research in an easy to understand presentation. The 20 percent of what you need to know in order to be 80 percent proficient!The authors who have operated various levels of businesses in the clinical research industry since 2005 believe that more practical information pertaining to clinical research needs to be accessible to individuals who are new to the industry or are curious about entering the rewarding world of clinical trials.This book reads in an easy to understand style and is based on proven methods the authors have developed to train their own employees and students of their various clinical research academies throughout the years. Picking this up and absorbing the information will allow anyone to gain much better insight into the complicated dynamics of clinical research. This practical roadmap is all you will need to get started on your clinical trial journey!In this book you will learn about:Regulations and the history as well as evolution of GCP.Clinical Research Site OperationsMonitoring Dynamics and Typical Monitoring VistsCRO ActivitiesSponsor Level DynamicsIndustry VendorsCommon Career Opportunities and Employment Roadmaps

Taxonomic Guide to Infectious Diseases: Understanding the Biologic Classes of Pathogenic Organisms, Second Edition tackles the complexity of clinical microbiology by assigning every infectious organism to one of 40+ taxonomic classes and providing a description of the defining traits that apply to all the organisms within each class. This edition is an updated, revised and greatly expanded guide to the classes of organisms that infect humans. This book will provide students and clinicians alike with a simplified way to understand the complex fields of clinical microbiology and parasitology. Focuses on human disease processes and includes numerous clinical tips for healthcare providers Describes the principles of classification and explains why the science of taxonomy is vital to the fields of bioinformatics and modern disease research Provides images of prototypical organisms for taxonomic classes Includes a section that lists common taxonomic pitfalls and how they can be avoided