While there are many excellent texts focused on clinical medical imaging, there are few books that approach in vivo imaging technologies from the perspective of a scientist or physician-scientist using, or interested in using, these techniques in research. It is for these individuals that Essentials of In Vivo Biomedical Imaging is written.Featurin

Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.

This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

Introduction to BiomedicalImaging A state-of-the-art exploration of the foundations and latest developments in biomedical imaging technology In the newly revised second edition of Introduction to Biomedical Imaging, distinguished researcher Dr. Andrew Webb delivers a comprehensive description of the fundamentals and applications of the most important current medical imaging techniques: X-ray and computed tomography, nuclear medicine, ultrasound, magnetic resonance imaging, and various optical-based methods. Each chapter explains the physical principles, instrument design, data acquisition, image reconstruction, and clinical applications of its respective modality. This latest edition incorporates descriptions of recent developments in photon counting CT, total body PET, superresolution-based ultrasound, phased-array MRI technology, optical coherence tomography, and iterative and model-based image reconstruction techniques. The final chapter discusses the increasing role of artificial intelligence/deep learning in biomedical imaging. The text also includes a thorough introduction to general image characteristics, including discussions of signal-to-noise and contrast-to-noise. Perfect for graduate and senior undergraduate students of biomedical engineering, Introduction to Biomedical Imaging, 2nd Edition will also earn a place in the libraries of medical imaging professionals with an interest in medical imaging techniques.

Radioisotope-based molecular imaging probes provide unprecedented insight into biochemistry and function involved in both normal and disease states of living systems, with unbiased in vivo measurement of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology including functional magnetic resonance imaging (fMRI) can provide such high sensitivity and specificity at a tracer level. The applications of this technology can be very broad ranging from drug development, pharmacokinetics, clinical investigations, and finally to routine diagnostics in radiology. The design and the development of radiopharmaceuticals for molecular imaging studies using PET/MicroPET or SPECT/MicroSPECT are a unique challenge. This book is intended for a broad audience and written with the main purpose of educating the reader on various aspects including potential clinical utility, limitations of drug development, and regulatory compliance and approvals.

This groundbreaking single-authored textbook equips students with everything they need to know to truly understand the hugely topical field of biomaterials science, including essential background on the clinical necessity of biomaterials, relevant concepts in biology and materials science, comprehensive and up-to-date coverage of all existing clinical and experimental biomaterials, and the fundamental principles of biocompatibility. It features extensive case studies interweaved with theory, from a wide range of clinical disciplines, equipping students with a practical understanding of the phenomena and mechanisms of biomaterials performance; a whole chapter dedicated to the biomaterials industry itself, including guidance on regulations, standards and guidelines, litigation, and ethical issues to prepare students for industry; informative glossaries of key terms, engaging end-of-chapter exercises and up-to-date lists of recommended reading. Drawing on the author's forty years' experience in biomaterials, this is an indispensable resource for students studying these lifesaving technological advances.

This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo. Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of updated cases that define and expand the didactic material in the clinical application chapters. Thoroughly updated and revised, the third edition incorporates new clinical evidence validating the use of radionuclides for diagnosis and therapy in oncology, new radiotracers, and the growing integration of imaging modalities into different types of hybrid imaging. With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Third Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.