Edited by world-renowned cardiologist Kenneth Ellenbogen, MD, and collaboratively written by five expert physicians and allied health professionals, Essential Concepts of Electrophysiology and Pacing through Case Studies guides the reader in developing and refining the key skill of analyzing tracings – one of the most essential proficiencies in electrophysiology. With 60 cases comprising more than 140 tracings, figures, and tables and accompanied by multiple-choice questions, this scholarly yet eminently practical text delineates the core concepts and brings the reader directly into each case, offering EP physicians and fellows, device representatives and engineers, and other allied health professionals a fundamental understanding of the most important concepts on which the practice of EP is based. Appropriate for professionals with different levels of proficiency, Essential Concepts of Electrophysiology and Pacing through Case Studies includes a wide array of basic to advanced tracings that range from surface ECGs to pacemaker and ICD recordings to complex intracardiac tracings that will prove vital in strengthening and sharpening practical skills. Relevant references included with each case allow the reader to delve even deeper into the principles presented and will be invaluable in helping to prepare for IBHRE, ABIM, and other EP certification exams.

This volume of intracardiac tracings builds on our first book, Essential Concepts of Electrophysiology and Pacing through Case Studies, that guides the reader in developing and refining the key skill of analyzing electrophysiologic recordings. Over 60 cases with a focus on intracardiac EGMs are presented as board exam cases and questions. Tracings are framed by a question, followed by annotated tracings, and a discussion of the correct and potential answers. Cases present a full range of difficulty from simple to advanced. This book will provide a valuable review for a wide variety of professionals — physicians, associated professionals, nurses and technicians — preparing for certification and re-certification examinations in electrophysiology.

This book offers a comprehensive review of clinical cardiac electrophysiology in a question and answer format. Chapters contain over 200 questions divided into 9 chapters, each organized by cardiac electrophysiology topic. Each question is followed by the correct answer with a detailed explanation along with references for further reading. Important concepts are highlighted and supported by over 200 illustrations and high resolution images. The book addresses a broad range of topics that are important when studying for the initial certification or recertification of the clinical cardiac electrophysiology board examination. It is also highly relevant for daily clinical practice in cardiology and cardiac electrophysiology. Topics covered in the book include: Review of basic and clinical cardiac electrophysiology principles associated with cardiac arrhythmias The evaluation and management of patients with cardiac rhythm disorders Review of pharmacologic and nonpharmacologic therapies for the treatment of arrhythmias Clinical indications, fundamental principles and electrical characteristics of implantable cardiac electronic devices such as pacemakers and defibrillators Clinical, electrocardiographic, and electrophysiologic characteristics of specific cardiac arrhythmia syndromes Cardiac Electrophysiology Board Review is a must-have resource for cardiology and cardiac electrophysiology trainees as well as attending physicians preparing for the certification or recertification examination. It may also be a useful guide for cardiologists, cardiac electrophysiologists and all clinicians who wish to further their understanding of heart rhythm disorders.

From senior electrophysiologist and world-class educator George Klein, a fully illustrated guide with over 100 intracardiac tracings and figures that allow the physician to approach electrophysiologic problems effectively and systematically. The book is especially focused on electrophysiological maneuvers and provides a clear and understandable guide to their proper selection and interpretation using abundant clinical examples. Defines the integral role for "traditional" electrogram (EGM) analysis in order to understand the mechanism of a tachycardia. It goes without saying that a correct arrhythmia diagnosis is a prerequisite to catheter ablation regardless of the presence of sophisticated mapping and imaging technologies. Electrophysiological maneuvers are fundamental to this process, and proper selection and interpretation of maneuvers constitute a core skill of the electrophysiologist. In this volume, we make the case that most maneuvers are fundamentally similar in principle and can be understood by appreciating a few basic physiological and anatomical principles. The art lies not in a comprehensive knowledge by rote of every maneuver or its application, but rather a systematic approach using common principles. We illustrate this by showing abundant examples and emphasizing the "game plan," including checklists that can be applied to virtually any maneuver. —George J. Klein In my opinion, this book should be on the shelf of every electrophysiologist trainee as well as every clinical cardiac electrophysiologist. It is a classic, like its editor. Dr. Klein deserves high praise for organizing his and his colleagues’ clinical experiences and thought processes into a concise, practical text that should be part of all training programs in electrophysiology. —From the foreword by Mark E. Josephson, MD

Bioconductor software has become a standard tool for the analysis and comprehension of data from high-throughput genomics experiments. Its application spans a broad field of technologies used in contemporary molecular biology. In this volume, the authors present a collection of cases to apply Bioconductor tools in the analysis of microarray gene expression data. Topics covered include: (1) import and preprocessing of data from various sources; (2) statistical modeling of differential gene expression; (3) biological metadata; (4) application of graphs and graph rendering; (5) machine learning for clustering and classification problems; (6) gene set enrichment analysis. Each chapter of this book describes an analysis of real data using hands-on example driven approaches. Short exercises help in the learning process and invite more advanced considerations of key topics. The book is a dynamic document. All the code shown can be executed on a local computer, and readers are able to reproduce every computation, figure, and table.

Questions relating to types of philosophical trends within African philosophy can be very decisive for any idea of African philosophy. In this strikingly novel approach to African Philosophy, the author explores a complementary philosophical trend that goes back to those he calls anonymous traditional African philosophers. Based on their thoughts, he articulates a distinctive variant of the principles, method and imperative of complementarity (Ibu anyi danda) around which he builds his system. He anchors his reflection on such ambient concepts as the joy of being (jide k' iji), fragmentation, wholeness, and future reference.

Neuronal communication forms the basis for all behavior, from the smallest movement to our grandest thought processes. Among the many mechanisms that support these functions, spike timing is among the most powerful and—until recently—perhaps the least studied. In the last two decades, however, the study of spike timing has exploded. The heightened interest is due to several factors. These include the development of physiological tools for measuring the activity of neural ensembles and analytical tools for assessing and characterizing spike timing. These advances are coupled with a growing appreciation of spike timing’s theoretical importance for the design principles of the brain. Spike Timing: Mechanisms and Function examines the function of spike timing in sensory, motor, and integrative processes, providing readers with a broad perspective on how spike timing is produced and used by the nervous system. It brings together the work and ideas of leaders in the field to address current thinking as well as future possibilities. The first section of the book describes the foundation for quantitative analysis and theory. It examines the information contained in spike timing, how it can be quantified, and how neural systems can extract it. The second section explores how input-output relationships are reflected in spike timing across a range of sensory systems. Drawing together multiple perspectives, including theoretical and computational studies as well as experimental studies in a range of model systems, the book provides a firm background for investigators to consider spike timing as it applies to their own work. It also offers a glimpse of future advances related to mechanisms of spike timing and its role in neural function, such as the development of novel computational technologies.