This is a handbook of methods and protocols for biologists. It aimed at undergraduate, graduate students and researchers originally trained in biological or medical sciences who need to know how to access the data archives of genomes, proteins, metabolites, gene expression profiles and the questions these data and tools can answer. For each chapter, the conceptual and experimental background is provided, together with specific guidelines for handling raw data, including preprocessing and analysis.The content is structured into three parts. Part one introduces basic knowledge about popular bioinformatics tools, databases and web resources. Part two presents examples of omics bioinformatics applications. Part three provides basic statistical analysis skills and programming skills needed to handle and analyze omics datasets.

An accessible guide to the ideas and technologies underlying such applications as GPS, Google Maps, Pokémon Go, ride-sharing, driverless cars, and drone surveillance. Billions of people around the globe use various applications of spatial computing daily—by using a ride-sharing app, GPS, the e911 system, social media check-ins, even Pokémon Go. Scientists and researchers use spatial computing to track diseases, map the bottom of the oceans, chart the behavior of endangered species, and create election maps in real time. Drones and driverless cars use a variety of spatial computing technologies. Spatial computing works by understanding the physical world, knowing and communicating our relation to places in that world, and navigating through those places. It has changed our lives and infrastructures profoundly, marking a significant shift in how we make our way in the world. This volume in the MIT Essential Knowledge series explains the technologies and ideas behind spatial computing. The book offers accessible descriptions of GPS and location-based services, including the use of Wi-Fi, Bluetooth, and RFID for position determination out of satellite range; remote sensing, which uses satellite and aerial platforms to monitor such varied phenomena as global food production, the effects of climate change, and subsurface natural resources on other planets; geographic information systems (GIS), which store, analyze, and visualize spatial data; spatial databases, which store multiple forms of spatial data; and spatial statistics and spatial data science, used to analyze location-related data.

Why cloud computing represents a paradigm shift for business, and how business users can best take advantage of cloud services. Most of the information available on cloud computing is either highly technical, with details that are irrelevant to non-technologists, or pure marketing hype, in which the cloud is simply a selling point. This book, however, explains the cloud from the user's viewpoint—the business user's in particular. Nayan Ruparelia explains what the cloud is, when to use it (and when not to), how to select a cloud service, how to integrate it with other technologies, and what the best practices are for using cloud computing. Cutting through the hype, Ruparelia cites the simple and basic definition of cloud computing from the National Institute of Science and Technology: a model enabling ubiquitous, convenient, on-demand network access to a shared pool of configurable computing resources. Thus with cloud computing, businesses can harness information technology resources usually available only to large enterprises. And this, Ruparelia demonstrates, represents a paradigm shift for business. It will ease funding for startups, alter business plans, and allow big businesses greater agility. Ruparelia discusses the key issues for any organization considering cloud computing: service level agreements, business service delivery and consumption, finance, legal jurisdiction, security, and social responsibility. He introduces novel concepts made possible by cloud computing: cloud cells, or specialist clouds for specific uses; the personal cloud; the cloud of things; and cloud service exchanges. He examines use case patterns in terms of infrastructure and platform, software information, and business process; and he explains how to transition to a cloud service. Current and future users will find this book an indispensable guide to the cloud.

Bits, bytes, RAM, CPUs, hard drives and dvd drives. Master the geeky acronyms and simplify computer hardware & terminology with ease. This book is great for beginners, a basic computing class, or someone looking to buy a computer.

Perfect for anyone who needs a basic understanding of how computers work, this introductory guide gives friendly, accessible, up-to-date explanations of computer hardware, software, networks, and the Internet. Coverage also includes micro-processors, operating systems, programming languages, applications, and e-commerce.

An introduction to applying predicate logic to testing and verification of software and digital circuits that focuses on applications rather than theory. Computer scientists use logic for testing and verification of software and digital circuits, but many computer science students study logic only in the context of traditional mathematics, encountering the subject in a few lectures and a handful of problem sets in a discrete math course. This book offers a more substantive and rigorous approach to logic that focuses on applications in computer science. Topics covered include predicate logic, equation-based software, automated testing and theorem proving, and large-scale computation. Formalism is emphasized, and the book employs three formal notations: traditional algebraic formulas of propositional and predicate logic; digital circuit diagrams; and the widely used partially automated theorem prover, ACL2, which provides an accessible introduction to mechanized formalism. For readers who want to see formalization in action, the text presents examples using Proof Pad, a lightweight ACL2 environment. Readers will not become ALC2 experts, but will learn how mechanized logic can benefit software and hardware engineers. In addition, 180 exercises, some of them extremely challenging, offer opportunities for problem solving. There are no prerequisites beyond high school algebra. Programming experience is not required to understand the book's equation-based approach. The book can be used in undergraduate courses in logic for computer science and introduction to computer science and in math courses for computer science students.