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El Libro de la vida es el primero que escribe santa Teresa, y constituye un buen reflejo de su personalidad y de su experiencia humana y sobrenatural. De corte autobiográfico, relata también el itinerario personalísimo de su oración. El volumen I comprende los aspectos más biográficos, y el volumen II el tratado sobre la oración. El manuscrito fue publicado por primera vez varios años después de la muerte de su autora.