This Special Issue explores the cross-disciplinary approaches, methodologies, and applications of socio-environmental vulnerability assessment that can be incorporated into sustainable management. The volume comprises 20 different points of view, which cover environmental protection and development, urban planning, geography, public policymaking, participation processes, and other cross-disciplinary fields. The articles collected in this volume come from all over the world and present the current state of the world’s environmental and social systems at a local, regional, and national level. New approaches and analytical tools for the assessment of environmental and social systems are studied. The practical implementation of sustainable development as well as progressive environmental and development policymaking are discussed. Finally, the authors deliberate about the perspectives of social–environmental systems in a rapidly changing world.