Definitions of species and speciation - - Strructural aspects of speciation - - Analytical techniques and methodology - - Bioaccessibility and bioavailability - - Toxicokinetics and biological monitoring - - Molecular and cellular mechanisms of metal toxicity - - Health effects - - Conclusions and recommendations.

Hardbound. This book provides a comprehensive discussion of the major aspects involved in elemental speciation. Sample preparation, separation techniques, instrumentation and quality assurance are all discussed. In addition, individual chapters are devoted to speciation of environmental samples and speciation of biological, clinical, and nutritional samples. Individual chapters are written by leaders in the field, and the book has been organized so that the reader may learn how to collect a sample and prepare it. Ways to separate and detect analytes of interest, and steps to take to ensure the validity of the measurements are also discussed. This book is unique in its comprehensive treatment of this subject.

The ongoing progress of science has shown that it is important for analytical scientists to determine not only the presence of particular elements, but also their species. There are many fields where this is applicable, and where there are a number of topics to be addressed. Developing separation and measurement systems for the many element species has tested the resourcefulness of analytical chemists over recent decades. A product of the EU sponsored Speciation 21 Network, this book presents a detailed review of the state-of-the-art of speciation issues in the occupational health, food and environment sectors, along with the main conclusions arising from discussions held during expert meetings. Topics covered include mercury and organotin compounds in the environment; factors affecting the health of workers; the importance of speciation of trace elements for health, and subsequent metabolism in the body; analytical methodologies; risk assessment; and legislation. Trace Element Speciation for Environment, Food and Health provides an insight into applied research in the speciation field and how it has become so important in all the fields represented. With its comprehensive coverage, it will be of particular interest to researchers in industry and academia, as well as government agencies and legislative bodies.

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication—the classic risk assessment paradigm—with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment. Covers fundamental risk assessment concerns for the effects of metals on human health Provides an easy-to-use structure to quickly locate specific methods Uses case studies to illustrate the methods and theories described Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health

Comprehensive and multidisciplinary presentation of the current trends in trace elements for human, animals, plants, and the environment This reference provides the latest research into the presence, characterization, and applications of trace elements and their role in humans, animals, and plants as well as their use in developing novel, functional feeds, foods, and fertilizers. It takes an interdisciplinary approach to the subject, describing the biological and industrial applications of trace elements. It covers various topics, such as the occurrence, role, and monitoring of trace elements and their characterization, as well as applications from the preliminary research to laboratory trials. Recent Advances in Trace Elements focuses on the introduction and prospects of trace elements; tackles environmental aspects such as sources of emission, methods of monitoring, and treatment/remediation processes; goes over the biological role of trace elements in plants, animals, and human organisms; and discusses the relevance of biomedical applications and commercialization. A compendium of recent knowledge in interdisciplinary trace element research Uniquely covers production and characterization of trace elements, as well as the industrial and biomedical aspects of their use Paves the way for the development of innovative products in diverse fields, including pharmaceuticals, food, environment, and materials science Edited by well-known experts in the field of trace elements with contributions from international specialists from a wide range of areas Unique in presenting comprehensive and multidisciplinary information of the key aspects of trace elements research in a digestible form, this book is essential reading for the novice and expert in the fields of environmental science, analytical chemistry, biochemistry, materials science, pharmaceutical science, nutraceutical, and pharmaceutical sciences. It is also valuable for companies that implement new products incorporating trace elements to the market.

The ongoing progress of science has shown that it is important for analytical scientists to determine not only the presence of particular elements, but also their species. There are many fields where this is applicable, and where there are a number of topics to be addressed. Developing separation and measurement systems for the many element species has tested the resourcefulness of analytical chemists over recent decades. A product of the EU sponsored Speciation 21 Network, this book presents a detailed review of the state-of-the-art of speciation issues in the occupational health, food and environment sectors, along with the main conclusions arising from discussions held during expert meetings. Topics covered include mercury and organotin compounds in the environment; factors affecting the health of workers; the importance of speciation of trace elements for health, and subsequent metabolism in the body; analytical methodologies; risk assessment; and legislation. Trace Element Speciation for Environment, Food and Health provides an insight into applied research in the speciation field and how it has become so important in all the fields represented. With its comprehensive coverage, it will be of particular interest to researchers in industry and academia, as well as government agencies and legislative bodies.