In the industrialized nations of the global North, well-funded agencies like the CDC attend to citizens' health, monitoring and treating for toxic poisons like lead. How do the under-resourced nations of the global South meet such challenges? In Edges of Exposure, Noémi Tousignant traces the work of toxicologists in Senegal as they have sought to warn of and remediate the presence of heavy metals and other poisons in their communities. Situating recent toxic scandals within histories of science and regulation in postcolonial Africa, Tousignant shows how decolonization and structural adjustment have impacted toxicity and toxicology research. Ultimately, as Tousignant reveals, scientists' capacity to conduct research—as determined by material working conditions, levels of public investment, and their creative but not always successful efforts to make visible the harm of toxic poisons—affects their ability to keep equipment, labs, projects, and careers going.

Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. - Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers - Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes - Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more

“For Erin Brockovich fans, a David vs. Goliath tale with a twist” (The New York Times Book Review)—the incredible true story of the lawyer who spent two decades building a case against DuPont for its use of the hazardous chemical PFOA, uncovering the worst case of environmental contamination in history—affecting virtually every person on the planet—and the conspiracy that kept it a secret for sixty years. The story that inspired Dark Waters, the major motion picture from Focus Features starring Mark Ruffalo and Anne Hathaway, directed by Todd Haynes. 1998: Rob Bilott is a young lawyer specializing in helping big corporations stay on the right side of environmental laws and regulations. Then he gets a phone call from a West Virginia farmer named Earl Tennant, who is convinced the creek on his property is being poisoned by runoff from a neighboring DuPont landfill, causing his cattle and the surrounding wildlife to die in hideous ways. Earl hasn’t even been able to get a water sample tested by any state or federal regulatory agency or find a local lawyer willing to take the case. As soon as they hear the name DuPont—the area’s largest employer—they shut him down. Once Rob sees the thick, foamy water that bubbles into the creek, the gruesome effects it seems to have on livestock, and the disturbing frequency of cancer and other health problems in the area, he’s persuaded to fight against the type of corporation his firm routinely represents. After intense legal wrangling, Rob ultimately gains access to hundreds of thousands of pages of DuPont documents, some of them fifty years old, that reveal the company has been holding onto decades of studies proving the harmful effects of a chemical called PFOA, used in making Teflon. PFOA is often called a “forever chemical,” because once in the environment, it does not break down or degrade for millions of years, contaminating the planet forever. The case of one farmer soon spawns a class action suit on behalf of seventy thousand residents—and the shocking realization that virtually every person on the planet has been exposed to PFOA and carries the chemical in his or her blood. What emerges is a riveting legal drama “in the grand tradition of Jonathan Harr’s A Civil Action” (Booklist, starred review) about malice and manipulation, the failings of environmental regulation; and one lawyer’s twenty-year struggle to expose the truth about this previously unknown—and still unregulated—chemical that we all have inside us.

The leading reference on probabilistic methods in combinatorics-now expanded and updated When it was first published in 1991, The Probabilistic Method became instantly the standard reference on one of the most powerful and widely used tools in combinatorics. Still without competition nearly a decade later, this new edition brings you up to speed on recent developments, while adding useful exercises and over 30% new material. It continues to emphasize the basic elements of the methodology, discussing in a remarkably clear and informal style both algorithmic and classical methods as well as modern applications. The Probabilistic Method, Second Edition begins with basic techniques that use expectation and variance, as well as the more recent martingales and correlation inequalities, then explores areas where probabilistic techniques proved successful, including discrepancy and random graphs as well as cutting-edge topics in theoretical computer science. A series of proofs, or "probabilistic lenses," are interspersed throughout the book, offering added insight into the application of the probabilistic approach. New and revised coverage includes: * Several improved as well as new results * A continuous approach to discrete probabilistic problems * Talagrand's Inequality and other novel concentration results * A discussion of the connection between discrepancy and VC-dimension * Several combinatorial applications of the entropy function and its properties * A new section on the life and work of Paul Erdös-the developer of the probabilistic method

John Russon draws from a broad range of art and literature to show how philosophy speaks to the most basic and important questions in our everyday lives. In Sites of Exposure, Russon grapples with how personal experiences such as growing up and confronting death combine with broader issues such as political oppression, economic exploitation, and the destruction of the natural environment to make life meaningful. His is cutting-edge philosophical work, illuminated by original and rigorous thinking that relies on cross-cultural communication and engagement with the richness of human cultural history. These probing interpretations of the nature of phenomenology, the philosophy of art, history, and politics, are appropriate for students and scholars of philosophy at all levels.