The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.

'This is one of the most powerful, real, relevant, and thought-provoking books I have picked up in some time.' The Art of Healing Have you ever wondered: Whether marijuana can lead to harder drugs. How come you feel immortal on speed. Why acid trips can feel so good - or so bad. Why total strangers bond on ecstasy. Whether drugs can enhance your spirituality. Why some antidepressants can make your depression worse. Higher and Higher offers a fresh perspective on every aspect of drugs from addiction to repair. Using a new analytical approach that fuses Traditional Chinese Medicine and Energy Medicine, it shows you how to integrate past drug experiences into your life in a positive way. Learn how to reclaim the excitement and exhilaration drugs offer, through a unique mind - body - spirit workout. Combining case studies with a candid account of Jost Sauer's own journey through drugs, depression and near self-destruction, to good health and freedom, Higher and Higher is in turn confronting, thought-provoking and informative. This uplifting and accessible read takes you on a roller-coaster ride from the relentless pursuit of drug-induced highs to genuine wellness. This unique book, based on Jost Sauer's personal and professional experience, provides invaluable insights into the human need to feel good, and details a healthy and sustainable path for you to reach the ultimate high. 'I have to say that you really hit it on the head with this one.' Anthony

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Arent they just getting high at taxpayers expense? Does it really ?Çÿeat your bones? Do they have to stay on that stuff forever? I thought Suboxone meant we wouldnt need methadone anymore. Learn the truth behind the Zombie effect Methadone is one tool in our fight against opiate dependency. As with any tool, it can be used, or it can be abused. We need every tool that we can get. Methadone is not the liquid handcuffs - the addiction is the handcuffs. Methadone can be the key to freedom from those handcuffs if it is used effectively. Addiction cant be contained by jail, and it wont be ignored. It will continue to pull down our culture until we acknowledge its power, and grapple with it in effective and realistic ways.

Providing a framework for treating substance use disorders (SUDs) in office-based psychotherapy, the second edition of this trusted work has been updated throughout and features two entirely new chapters. The authors show how clinicians from any background can leverage the therapeutic skills they already have to address clients' alcohol and drug problems competently and effectively. Vivid case examples demonstrate ways to engage clients at different stages of change; set collaborative treatment goals; address SUDs concurrently with other psychological problems; and interweave motivational, cognitive-behavioral, and other interventions, tailored to each individual's needs. Reproducible forms and handouts can be downloaded and printed in a convenient 8 1/2" x 11" size. New to This Edition *Chapter on evidence-based principles and interventions. *Chapter on moderation-focused alcohol treatment. *Revised throughout with current data, clinical techniques, and examples. *Reflects over 15 years of important changes in the field--increased demand for integrated treatment, the ongoing opioid crisis, the growth of harm reduction and medication-assisted treatments, and more.

"Joe's story is important because it tells how a person or family struggling with addictions can find success working a combination of biochemical repair along with the standard mental/emotional program for addictions." --Dr. Bill Billica DYING FOR PLEASURE IS NO WAY TO LIVE Joe Eisele knows this firsthand. He became addicted to alcohol and drugs as a teenager, and only found the path to recovery by incorporating biochemical restoration into his treatment. In Leaving Drug and Alcohol Addictions for Good, readers experience the frightening ride on what Joe calls "the addiction train." Joe's story is layered with Sharon's, whose son became caught in the devastating, often deadly trajectory of addiction while Joe and Sharon were working on this book. "There is a big difference between finding pleasure in what life brings and and chasing pleasure at any cost," says Joe, the co-founder and clinical director of InnerBalance Health Center in Loveland, Colorado. His treatment center for people with drug and alcohol addictions includes the critical component often missing from other programs: biochemical restoration. Whether you are coping with addiction yourself or trying to help someone else get off the addiction train, you'll find a deep understanding and empathy in Joe's story, and fresh hope in how you truly can leave drug and alcohol addictions for good.