Drug-Nucleic Acid Interactions
Title | Drug-Nucleic Acid Interactions PDF eBook |
Author | |
Publisher | Elsevier |
Pages | 740 |
Release | 2001-07-31 |
Genre | Medical |
ISBN | 0080496903 |
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.
Methods for Studying Nucleic Acid/Drug Interactions
Title | Methods for Studying Nucleic Acid/Drug Interactions PDF eBook |
Author | Meni Wanunu |
Publisher | CRC Press |
Pages | 397 |
Release | 2016-04-19 |
Genre | Medical |
ISBN | 1439839743 |
Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the eff
Drug-DNA Interactions
Title | Drug-DNA Interactions PDF eBook |
Author | Kazuo Nakamoto |
Publisher | John Wiley & Sons |
Pages | 475 |
Release | 2008-09-08 |
Genre | Science |
ISBN | 0470369167 |
Learn vital information about drug-DNA interactions from Drug-DNA Interactions: Structures and Spectra, the only comprehensive book written about this topic. Understand the types of structural and bonding information that can be obtained using specific physico-chemical methods and discover how to design new drugs that are more effective than current treatments and have fewer side effects. Find detailed information about X-ray crystallography, NMR spectroscopy, molecular modeling, and optical spectroscopy such as UV-Visible absorption, fluorescence, circular dichroism (CD), flow linear dichroism (FLD), infrared (IR) and Raman spectroscopy.
Molecular Basis of Specificity in Nucleic Acid-Drug Interactions
Title | Molecular Basis of Specificity in Nucleic Acid-Drug Interactions PDF eBook |
Author | A. Pullman |
Publisher | Springer |
Pages | 603 |
Release | 2012-10-29 |
Genre | Science |
ISBN | 9789401056571 |
One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
Molecular Aspects of Anticancer Drug DNA Interactions
Title | Molecular Aspects of Anticancer Drug DNA Interactions PDF eBook |
Author | Stephen Neidle |
Publisher | CRC Press |
Pages | 386 |
Release | 1994-05-03 |
Genre | Medical |
ISBN | 9780849377730 |
This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.
DNA-Ligand Interactions
Title | DNA-Ligand Interactions PDF eBook |
Author | W. Guschlbauer |
Publisher | Springer |
Pages | 290 |
Release | 2013-06-14 |
Genre | Science |
ISBN | 9781468453843 |
This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th. 1986 in the Abbey of Fontevraud (France). The ASI was attended by 112 participants from a wide scientific horizon and from twentyone different countries. It was in some way a follow-up of the ASI held in Maratea. Italy in May 1981 and which was published in the NATO ASI Life Science series as volume 45. While much has been learned about the way the cellular machinery maintains and transmits the genetic heritage. as well as how these processes are regulated. little is Known about how the interactions between the various partners involved are taKing place. The interactions of drugs and proteins with nucleic acids are of evident importance in the understanding of these problems. The spectacular advances in recombinant DNA technology and the increased sophistication of biophysical techniques. in particular >:-ray diffraction and nuclear magnetic resonance. have created a scientific environment which is highly promising for the future of research in molecular biology. These advances permH the serious hope that biology on the molecular level may become a r-eality. Some of the contributions at the ASI presented the most recent advances in this e>:citing field.
Molecular Basis of Specificity in Nucleic Acid-Drug Interactions
Title | Molecular Basis of Specificity in Nucleic Acid-Drug Interactions PDF eBook |
Author | A. Pullman |
Publisher | Springer Science & Business Media |
Pages | 595 |
Release | 2012-12-06 |
Genre | Science |
ISBN | 9401137285 |
One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.