The notion that drugs can induce valvular heart disease (VHD) has occurred since the sixties and has received a lot of attention in recent years. Overstimulation of the serotonin 2B receptor (5-HT2B) leads to valvular fibroblast proliferation and thickening of the valvular leaflets with reduced mobility and regurgitation as a consequence. This new book focuses on different aspects of this distinct kind of valvulopathy including pathophysiology of drug-induced VHD, histopathological and echocardiographic characteristics, drugs associated with VHD, the influence of cumulative drug dose and risk factors and others.

Since the first edition of this book was published in 2005, drug therapy has seen both breakthrough advances and sobering setbacks. The changes will continue. That's why every health care professional, hospital and health system, pharmacy, and medical school needs this invaluable reference. It will help you detect, prevent and manage drug-related diseases. And also remind you to always ask yourself the increasingly critical question: "Could this disease be drug-related?"

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. - Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. - International editors and chapter authors ensure a truly global perspective. - Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. - Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. - Consolidates today's available information and guidance into a single, convenient resource.

A definitive resource, The ESC Textbook of Cardiovascular Imaging, second edition provides extensive coverage of all cardiovascular imaging modalities. Produced in collaboration with the European Association of Cardiovascular Imaging with contributions from specialists across the globe and edited by a distinguished team of experts, it is a 'state of the art' clinically-orientated imaging reference. Now fully revised and updated with the latest imaging techniques and technology and covering even more conditions than before, it not only discusses the principles of individual modalities but also clearly demonstrates the added value each technique can bring to the treatment of all cardiac diseases. Richly illustrated with colour figures, images, and tables and using a wealth of newly available evidence to link theory to practice, it demonstrates how these techniques can be used in the diagnosis of a range of cardiovascular diseases. Learning how to apply them in practice is made easy with free access to videos and imaging loops online along with the full text so that it is always available, even when on the move. Impressive in scope, The ESC Textbook of Cardiovascular Imaging contains information on cutting-edge technical developments in echocardiography, CT, CMR and hybrid imaging and well imaging's current role in cardiac interventions, such as identifying cardiac structures, helping to guide procedures and exclude possible complications. The application of imaging modalities in conditions such as valvular and coronary heart disease, heart failure, cardiomyopathies, peri-myocardioal disease, adult congenital heart disease and aortic disease, is also extensively considered. From discussion on improved imaging techniques and advances in technology, to guidance and explanation of key practices and theories, this new edition of The ESC Textbook of Cardiovascular Imaging is the ideal reference guide for cardiologists and radiologists alike. This print edition of The ESC Textbook of Cardiovascular Imaging comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.