This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

American Association for Cancer Research 2019 Proceedings: Abstracts 2749-5314 - Part B

Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of biological science. Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research. Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research. Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis Explores cellular to systems development in key biomedical model organisms Timely synthesis of the field of Xenopus biology Highlights key biomedical and basic biological findings unlocked by Xenopus

For more than 60 years, Shackelford's Surgery of the Alimentary Tract has served as the cornerstone reference in this fast-moving field. With comprehensive coverage of all aspects of GI surgery, the 8th Edition, by Drs. Charles J. Yeo, Steven R. DeMeester, David W. McFadden, Jeffrey B. Matthews, and James W. Fleshman, offers lavishly illustrated, authoritative guidance on endoscopic, robotic, and minimally invasive procedures, as well as current medical therapies. Each section is edited by a premier authority in GI surgery; chapters reflect key topics and are written by a "who's who" of international experts in the field. It's your one-stop resource for proven, systematic approaches to all relevant adult and pediatric GI disorders and operations - Features an abundance of beautifully detailed intraoperative and laparoscopic photographs, as well as radiographs and line drawings, to enhance and clarify the text. - Presents essential information, such as lists of differential diagnoses, in tabular format for quick reference. - Discusses recent, major advances in minimally invasive surgery and robotic surgery, personalized therapy based on genomics and proteomics, and new pharmacologic treatments of various GI diseases. - Includes all-new information on laparoscopy for rectal cancer, sacral nerve stimulation for incontinence and constipation, management of Crohn's disease and ulcerative colitis, advances in immunosuppression for transplant patients, and new therapies for inflammatory bowel disease. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.