One approach to organic synthesis is retrosynthetic analysis. With this approach chemists start with the structures of their target molecules and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course. Workbook for Organic Synthesis: The Disconnection Approach, 2nd Edition This workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: The Disconnection Approach, 2nd Edition. Each problem is followed by a fully explained solution and discussion. The examples extend the student’s experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given. Together the workbook and textbook provide a complete course in retrosynthetic analysis. Organic Synthesis: The Disconnection Approach, 2nd Edition There are forty chapters in Organic Synthesis: The Disconnection Approach, 2nd Edition: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems. In its second edition updated examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, Organic Synthesis: Strategy and Control. Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry. Workbook for Organic Synthesis: The Disconnection Approach, 2nd edition, combined with the main textbook, provides a full course in retrosynthetic analysis for chemistry and biochemistry students, and a refresher course for organic chemists working in industry and academia.

In many ways, divorce is a quintessentially personal decision—the choice to leave a marriage that causes harm or feels unfulfilling to the two people involved. But anyone who has gone through a divorce knows the additional public dimensions of breaking up, from intense shame and societal criticism to friends’ and relatives’ unsolicited advice. In Intimate Disconnections, Allison Alexy tells the fascinating story of the changing norms surrounding divorce in Japan in the early 2000s, when sudden demographic and social changes made it a newly visible and viable option. Not only will one of three Japanese marriages today end in divorce, but divorces are suddenly much more likely to be initiated by women who cite new standards for intimacy as their motivation. As people across Japan now consider divorcing their spouses, or work to avoid separation, they face complicated questions about the risks and possibilities marriage brings: How can couples be intimate without becoming suffocatingly close? How should they build loving relationships when older models are no longer feasible? What do you do, both legally and socially, when you just can’t take it anymore? Relating the intensely personal stories from people experiencing different stages of divorce, Alexy provides a rich ethnography of Japan while also speaking more broadly to contemporary visions of love and marriage during an era in which neoliberal values are prompting wide-ranging transformations in homes across the globe.

Disentangles the complex reasons behind why people get into debt and are then disconnected from their gas supply.

This book is based on the author's PhD thesis which was selected during the 1993 ACM Doctoral Dissertation Competition as one of the three best submissions. The focus of this work is on the issue of availability in distributed file systems. It presents the important new technique called disconnected operation, in which clients mask failures and voluntary network detachments by emulating the functionality of servers where actual server-oriented solutions are inadequate. This permits client operation even under complete isolation from the server; the clean integration of mobile computers into the system is an important side-effect of the new technique. The design and implementation of disconnected file service in a working system, the Coda file system, is described in detail.

With 40% new material the new edition of Advanced Wireless Networks provides a comprehensive representation of the key issues in 4G wireless networks. Focussing on cognitive, cooperative and opportunistic paradigms to provide further increase in network efficiency, the book explores and addresses issues in wireless internet, mobile cellular and WLAN, as well as sensor, ad hoc, bio-inspired, active and cognitive networks. It examines the problem of cross-layer optimisation and network information theory as well as adaptability and reconfigurability in wireless networks. This book is an integral description of future wireless networks and the interconnection between their elements. The information is presented in a logical order within each chapter making it ideal for all levels of reader including researchers involved in modelling and analysis of future networks as well as engineers working in the area. Each chapter starts with introductory material and gradually includes more sophisticated models and mathematical tools concluding with a comprehensive list of references. Fully updated throughout with five new chapters on Opportunistic Communications; Relaying and Mesh Networks; Topology Control; Network Optimization; and Cognitive Radio Resource Management Unifies the latest research on cognitive, cooperative and opportunistic paradigms in wireless communications Provides efficient analytical tools for network analysis Discusses security issues, an essential element of working with wireless networks Supports advanced university and training courses in the field Companion website containing extra appendix on Queuing theory

The use of unmanned aerial vehicles (UAVs) plays an important role in supporting human activities. Man is concentrating more and more on intellectual work, and trying to automate practical activities as much as possible in order to increase their efficiency. In this regard, the use of drones is increasingly becoming a key aspect of this automation process, offering many advantages, including agility, efficiency and reduced risk, especially in dangerous missions. Hence, this Special Issue focuses on applications, platforms and services where UAVs can be used as facilitators for the task at hand, also keeping in mind that security should be addressed from its different perspectives, ranking from communications security to operational security, and furthermore considering privacy issues.