Here's instant access to the symptoms, signs, differential diagnosis, and treatment for the full range of liver disorders. Written by an international 'who's who' of hepatology-and now in full color-this new 2nd Edition provides readers with top-notch, authoritative guidance they can count on! Discusses the hottest topics in the field, such as non-alcoholic steatohepatitis (NASH) and the latest information on liver transplantation. Includes expanded coverage of chronic hepatitis C, most notably the use of combination therapy with peginterferon and ribavirin and improvements in the management of the side effects of antiviral therapy. Offers the most recent therapeutic options for the management of chronic hepatitis B and advances in the understanding of the molecular biology of this virus. Updates the approach to the diagnosis of many liver diseases due to newer tests based on molecular techniques and advances in imaging. Features over 340 full-color illustrations. Uses a redesigned templated, outline format that makes reference a snap. Presents a concise, in-depth clinical summary-in an outline format-of the current practice of hepatology for each major disease entity. Provides a liberal use of tables, algorithms, and figures, rendering complex concepts understandable. Includes key point boxes at the beginning of each chapter, providing at-a-glance access to vital information. Includes alert symbols that highlight information that's critical to patient safety.

This book provides a unique up-to-date and comprehensive overview of the most important diagnostic methods available for assessing liver cirrhosis and portal hypertension. The book covers all the significant advances made in the last 10 years in HVPG and biopsy interpretation, imaging and elastography. This is a unique and well structured book authored by senior experts in the field aimed at providing updated knowledge to the hepatology specialist and to the physicians interested in chronic liver disease. The book starts by giving an overview of the disease, outlining the clinical needs in this field; this is followed by detailed information both on the invasive gold-standard methods (HVPG measurement, liver biopsy, endoscopy), and on the standard and emerging non-invasive methods, including serum markers of fibrosis, ultrasound-elastography, magnetic resonance elastography, ultrasound, contrast-enhanced ultrasound, CT, magnetic resonance and derived methods (dynamic flow assessment). The final part of the book is devoted to diagnostic tests in non-cirrhotic causes of portal hypertension (Budd-Chiari Syndrome, Portal vein thrombosis, idiopathic portal hypertension, etc), and in pediatric portal hypertension. Written by a team of worldwide opinion leaders this book pays special attention to the most promising novel non-invasive methods in the field.

The definitive work on the diagnosis and treatment of portal hypertension Previously published by the Society for Interventional Radiology (SIR), this fully revised and updated third edition of Portal Hypertension: Imaging, Diagnosis, and Endovascular Management is the first volume in collaboration between Thieme and the SIR. Edited by Wael Saad and written by internationally recognized experts, this authoritative volume is a comprehensive guide to the diagnosis and interventional management of portal hypertension. A potentially serious condition, portal hypertension presents considerable clinical challenges due to the delicate nature of the impacted organs, veins, and vessels. From pathophysiology to the latest state-of-the-art approaches, five major sections encompass diagnostic, medical, endoscopic, non-vascular, surgical, percutaneous, endovascular, and balloon-occluded methodologies, including indications, complications, and clinical trial results. Throughout this book's 33 chapters, a Who's Who of world-renowned interventional radiologists share clinical pearls and step-by-step procedural guidance. Several techniques have undergone significant advances since the second edition was published, including Transjugular Intrahepatic Portosystemic Shunt (TIPS), Balloon-Occluded Retrograde Transvenous Obliteration (BRTO), Balloon-Occluded Antegrade Transvenous Obliteration (BATO), and variations on TIPS, and all these are featured herein. Key Highlights Hepatic and portal venous anatomy relative to procedural approaches Nearly 250 figures elucidate anatomical structures and technical methodologies TIPS: patient selection, effects on kidney and liver function, hemodynamic changes, intravascular ultrasound guidance, Doppler surveillance, and utilization for Budd-Chiari Syndrome and liver transplantation TIPS clinical study outcomes for variceal bleeding, ascites, and hydrothorax BRTO and BATO techniques, clinical study outcomes, and utilization for gastric varices Management of mesenteric and portal vein stenosis, thrombosis, and hypersplenism This remarkable book is a must-have tool for interventional radiologists and for all those who care for patients with portal hypertension, from residents to practicing clinicians.

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

This book provides a comprehensive account on individually rare, but collectively frequent diseases of the liver. In the first part, conditions such as hepatic vascular malformations, ischemic cholangiopathy, hepatic artery occlusion, sinusoidal conditions and Budd-Chiari syndrome are discussed among others. The second part examines the causes of vascular liver disease namely, coagulation disorders, neoplasm disorders, non-malignant blood disorders, systemic diseases and toxins, among others. The unique expertise of the authors, who are all members of the Vascular Liver Disease Disorders Group, an independent network of researchers with a common interest in Vascular Liver Diseases, are merged for an optimal pragmatic and individualized approach. This book is of interest to a broad range of experts, such as hepatologists, internists, radiologists and angiologists.

Cirrhosis: a practical guide to management provides gastroenterologists and hepatologists with an up-to-date clinical guide presenting the very best evidence-based practice in the diagnosis, treatment and management of liver cirrhosis and its many complications. Designed to offer practical guidance at all times, it provides doctors with an extremely useful tool in the clinical setting, with each chapter featuring diagnostic/management algorithms, key points and other pedagogic features. Divided into 2 parts, a diagnosis and pathophysiology section and a management of complications section, key topics include: - Diagnostic laboratory tests - Diagnostic imaging modalities - Acute-on chronic liver failure - Agents and drugs to avoid - End stage liver failure: liver transplant evaluation - Hepatocellular carcinoma Aimed at the specialist, as well as the practicing trainee at the top-end of specialty training, the emphasis throughout is on providing optimum clinical management guidance most relevant to practicing hepatologists and gastroenterologists, and is an invaluable guide to this increasingly common condition.