Diagnosis and Management of Mitochondrial Disorders
Title | Diagnosis and Management of Mitochondrial Disorders PDF eBook |
Author | Michelangelo Mancuso |
Publisher | Springer |
Pages | 382 |
Release | 2019-05-03 |
Genre | Medical |
ISBN | 3030055175 |
This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.
Mitochondrial Dysfunction
Title | Mitochondrial Dysfunction PDF eBook |
Author | Lawrence H. Lash |
Publisher | Elsevier |
Pages | 527 |
Release | 2013-10-22 |
Genre | Science |
ISBN | 1483218619 |
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Diagnosis and Management of Mitochondrial Disorders
Title | Diagnosis and Management of Mitochondrial Disorders PDF eBook |
Author | Michelangelo Mancuso |
Publisher | |
Pages | |
Release | 2019 |
Genre | Mitochondrial DNA |
ISBN | 9783030055189 |
This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world's foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.
Clinical Mitochondrial Medicine
Title | Clinical Mitochondrial Medicine PDF eBook |
Author | Patrick F. Chinnery |
Publisher | Cambridge University Press |
Pages | 229 |
Release | 2018-05-17 |
Genre | Medical |
ISBN | 0521132983 |
This interactive clinical textbook takes a system- and case-based approach in understanding mitochondrial disorders in clinical practice.
Mitochondrial Medicine
Title | Mitochondrial Medicine PDF eBook |
Author | Saskia Koene |
Publisher | |
Pages | 135 |
Release | 2011 |
Genre | |
ISBN | 9789081773706 |
Mitochondrial Diseases
Title | Mitochondrial Diseases PDF eBook |
Author | Placido Navas |
Publisher | Springer Nature |
Pages | 308 |
Release | 2021-07-30 |
Genre | Medical |
ISBN | 3030701476 |
Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach. This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options. Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research. This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.
Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease
Title | Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease PDF eBook |
Author | Iain P. Hargreaves |
Publisher | MDPI |
Pages | 239 |
Release | 2018-10-16 |
Genre | Science |
ISBN | 3038972401 |
This book is a printed edition of the Special Issue "Current Strategies for the Biochemical Diagnosis and Monitoring of Mitochondrial Disease" that was published in JCM