Improving the Utility and Translation of Animal Models for Nervous System Disorders
Title | Improving the Utility and Translation of Animal Models for Nervous System Disorders PDF eBook |
Author | Institute of Medicine |
Publisher | National Academies Press |
Pages | 111 |
Release | 2013-04-25 |
Genre | Medical |
ISBN | 0309266335 |
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.
The Design and Statistical Analysis of Animal Experiments
Title | The Design and Statistical Analysis of Animal Experiments PDF eBook |
Author | Simon T. Bate |
Publisher | Cambridge University Press |
Pages | 327 |
Release | 2014-03-13 |
Genre | Computers |
ISBN | 1107030781 |
This book will provide scientists with a better understanding of statistics, improving their decision-making and reducing animal use.
Use of Laboratory Animals in Biomedical and Behavioral Research
Title | Use of Laboratory Animals in Biomedical and Behavioral Research PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Pages | 113 |
Release | 1988-02-01 |
Genre | Science |
ISBN | 0309038391 |
Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
Design and Analysis of Animal Studies in Pharmaceutical Development
Title | Design and Analysis of Animal Studies in Pharmaceutical Development PDF eBook |
Author | Shein-Chung Chow |
Publisher | CRC Press |
Pages | 430 |
Release | 1998-01-15 |
Genre | Mathematics |
ISBN | 9780824701307 |
"Provides well-integrated, comprehensive coverage of all the major statistical designs and methods used for animal studies in pharmaceutical research and development. Demonstrates the correct way to interpret the results of animal studies in the risk assessment of biopharmaceutical products and clarifies detailed presentations with real-world examples. "
Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity
Title | Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Pages | 261 |
Release | 2001-04-13 |
Genre | Nature |
ISBN | 0309073162 |
The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).
Improving and Accelerating Therapeutic Development for Nervous System Disorders
Title | Improving and Accelerating Therapeutic Development for Nervous System Disorders PDF eBook |
Author | Institute of Medicine |
Publisher | National Academies Press |
Pages | 107 |
Release | 2014-02-06 |
Genre | Medical |
ISBN | 0309292492 |
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Principles of Animal Research for Graduate and Undergraduate Students
Title | Principles of Animal Research for Graduate and Undergraduate Students PDF eBook |
Author | Mark A. Suckow |
Publisher | Academic Press |
Pages | 288 |
Release | 2016-11-16 |
Genre | Psychology |
ISBN | 012802366X |
Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher's education. - Provides background material for students to understand the broader backdrop against which animal research is undertaken - Includes ethical and regulatory information - Covers commonly used animal models and the process to choose a model for biomedical research