This book provides a comprehensive overview of deep learning (DL) in medical and healthcare applications, including the fundamentals and current advances in medical image analysis, state-of-the-art DL methods for medical image analysis and real-world, deep learning-based clinical computer-aided diagnosis systems. Deep learning (DL) is one of the key techniques of artificial intelligence (AI) and today plays an important role in numerous academic and industrial areas. DL involves using a neural network with many layers (deep structure) between input and output, and its main advantage of is that it can automatically learn data-driven, highly representative and hierarchical features and perform feature extraction and classification on one network. DL can be used to model or simulate an intelligent system or process using annotated training data. Recently, DL has become widely used in medical applications, such as anatomic modelling, tumour detection, disease classification, computer-aided diagnosis and surgical planning. This book is intended for computer science and engineering students and researchers, medical professionals and anyone interested using DL techniques.

Before the modern age of medicine, the chance of surviving a terminal disease such as cancer was minimal at best. After embracing the age of computer-aided medical analysis technologies, however, detecting and preventing individuals from contracting a variety of life-threatening diseases has led to a greater survival percentage and increased the development of algorithmic technologies in healthcare. Deep Learning Applications in Medical Imaging is a pivotal reference source that provides vital research on the application of generating pictorial depictions of the interior of a body for medical intervention and clinical analysis. While highlighting topics such as artificial neural networks, disease prediction, and healthcare analysis, this publication explores image acquisition and pattern recognition as well as the methods of treatment and care. This book is ideally designed for diagnosticians, medical imaging specialists, healthcare professionals, physicians, medical researchers, academicians, and students.

This book constitutes the refereed proceedings of two workshops held at the 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016, in Athens, Greece, in October 2016: the First Workshop on Large-Scale Annotation of Biomedical Data and Expert Label Synthesis, LABELS 2016, and the Second International Workshop on Deep Learning in Medical Image Analysis, DLMIA 2016. The 28 revised regular papers presented in this book were carefully reviewed and selected from a total of 52 submissions. The 7 papers selected for LABELS deal with topics from the following fields: crowd-sourcing methods; active learning; transfer learning; semi-supervised learning; and modeling of label uncertainty.The 21 papers selected for DLMIA span a wide range of topics such as image description; medical imaging-based diagnosis; medical signal-based diagnosis; medical image reconstruction and model selection using deep learning techniques; meta-heuristic techniques for fine-tuning parameter in deep learning-based architectures; and applications based on deep learning techniques.

Deep Learning for Medical Applications with Unique Data informs readers about the most recent deep learning-based medical applications in which only unique data gathered in real cases are used. The book provides examples of how deep learning can be used in different problem areas and frameworks in both clinical and research settings, including medical image analysis, medical image registration, time series analysis, medical data synthesis, drug discovery, and pre-processing operations. The volume discusses not only positive findings, but also negative ones obtained by deep learning techniques, including the use of newly developed deep learning techniques rarely reported in the existing literature. The book excludes research works with ready data sets and includes only unique data use to better understand the state of deep learning in real-world cases, along with the feedback and user experiences from physicians and medical staff for applied deep learning-based solutions. Other applications presented in the book include hybrid solutions with deep learning support, disease diagnosis with deep learning focusing on rare diseases and cancer, patient care and treatment, genomics research, as well as research on robotics and autonomous systems. - Introduces deep learning, demonstrating concepts for a wide variety of medical applications using unique data, excluding research with ready datasets - Encompasses a wide variety of biomedical applications, including unsupervised learning, natural language processing, pattern recognition, image and video processing and disease diagnosis - Provides a robust set of methods that will help readers appropriately and judiciously use the most suitable deep learning techniques for their applications

This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.

Over the past 40 years, diagnostic medical imaging has undergone remarkable advancements in CT, MRI, and ultrasound technology. Today, the field is experiencing a major paradigm shift, thanks to significant and rapid progress in deep learning techniques. As a result, numerous innovative AI-based programs have been developed to improve image quality and enhance clinical workflows, leading to more efficient and accurate diagnoses. AI advancements of medical imaging not only address existing unsolved problems but also present new and complex challenges. Solutions to these challenges can improve image quality and reveal new information currently obscured by noise, artifacts, or other signals. Holistic insight is the key to solving these challenges. Such insight may lead to a creative solution only when it is based on a thorough understanding of existing methods and unmet demands. This book focuses on advanced topics in medical imaging modalities, including CT and ultrasound, with the aim of providing practical applications in the healthcare industry. It strikes a balance between mathematical theory, numerical practice, and clinical applications, offering comprehensive coverage from basic to advanced levels of mathematical theories, deep learning techniques, and algorithm implementation details. Moreover, it provides in-depth insights into the latest advancements in dental cone-beam CT, fetal ultrasound, and bioimpedance, making it an essential resource for professionals seeking to stay up-to-date with the latest developments in the field of medical imaging.

Deep Learning (DL) is a method of machine learning, running over Artificial Neural Networks, that uses multiple layers to extract high-level features from large amounts of raw data. Deep Learning methods apply levels of learning to transform input data into more abstract and composite information. Handbook for Deep Learning in Biomedical Engineering: Techniques and Applications gives readers a complete overview of the essential concepts of Deep Learning and its applications in the field of Biomedical Engineering. Deep learning has been rapidly developed in recent years, in terms of both methodological constructs and practical applications. Deep Learning provides computational models of multiple processing layers to learn and represent data with higher levels of abstraction. It is able to implicitly capture intricate structures of large-scale data and is ideally suited to many of the hardware architectures that are currently available. The ever-expanding amount of data that can be gathered through biomedical and clinical information sensing devices necessitates the development of machine learning and AI techniques such as Deep Learning and Convolutional Neural Networks to process and evaluate the data. Some examples of biomedical and clinical sensing devices that use Deep Learning include: Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Ultrasound, Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), Magnetic Particle Imaging, EE/MEG, Optical Microscopy and Tomography, Photoacoustic Tomography, Electron Tomography, and Atomic Force Microscopy. Handbook for Deep Learning in Biomedical Engineering: Techniques and Applications provides the most complete coverage of Deep Learning applications in biomedical engineering available, including detailed real-world applications in areas such as computational neuroscience, neuroimaging, data fusion, medical image processing, neurological disorder diagnosis for diseases such as Alzheimer’s, ADHD, and ASD, tumor prediction, as well as translational multimodal imaging analysis. Presents a comprehensive handbook of the biomedical engineering applications of DL, including computational neuroscience, neuroimaging, time series data such as MRI, functional MRI, CT, EEG, MEG, and data fusion of biomedical imaging data from disparate sources, such as X-Ray/CT Helps readers understand key concepts in DL applications for biomedical engineering and health care, including manifold learning, classification, clustering, and regression in neuroimaging data analysis Provides readers with key DL development techniques such as creation of algorithms and application of DL through artificial neural networks and convolutional neural networks Includes coverage of key application areas of DL such as early diagnosis of specific diseases such as Alzheimer’s, ADHD, and ASD, and tumor prediction through MRI and translational multimodality imaging and biomedical applications such as detection, diagnostic analysis, quantitative measurements, and image guidance of ultrasonography