Imagine life as a doctor on the high seas.

What won’t we try in our quest for perfect health, beauty, and the fountain of youth? Well, just imagine a time when doctors prescribed morphine for crying infants. When liquefied gold was touted as immortality in a glass. And when strychnine—yes, that strychnine, the one used in rat poison—was dosed like Viagra. Looking back with fascination, horror, and not a little dash of dark, knowing humor, Quackery recounts the lively, at times unbelievable, history of medical misfires and malpractices. Ranging from the merely weird to the outright dangerous, here are dozens of outlandish, morbidly hilarious “treatments”—conceived by doctors and scientists, by spiritualists and snake oil salesmen (yes, they literally tried to sell snake oil)—that were predicated on a range of cluelessness, trial and error, and straight-up scams. With vintage illustrations, photographs, and advertisements throughout, Quackery seamlessly combines macabre humor with science and storytelling to reveal an important and disturbing side of the ever-evolving field of medicine.

A remarkable new historical thriller by New York Times notable mystery author Lawrence Goldstone that evokes the New York City of 1899. In 1899, in Brooklyn, New York, Dr. Noah Whitestone is called urgently to his wealthy neighbor’s house to treat a five-year-old boy with a shocking set of symptoms. When the child dies suddenly later that night, Noah is accused by the boy’s regular physician—the powerful and politically connected Dr. Arnold Frias—of prescribing a lethal dose of laudanum. To prove his innocence, Noah must investigate the murder—for it must be murder—and confront the man whom he is convinced is the real killer. His investigation leads him to a reporter for a muckraking magazine and a beautiful radical editor who are convinced that a secret, experimental drug from Germany has caused the death of at least five local children, and possibly many more. Noah is drawn into a dangerous world of drugs, criminals, and politics, which threatens not just his career but also his life. Goldstone weaves a savvy tale of intrigue and stunning twists that incorporates real-life historical figures and events while richly recreating the closing days of the nineteenth century—a time when American might was on the march in the Pacific, medicine was poised to leap into a new era, radical politics threatened the status quo, and the role of women in American society was undergoing profound change.

Recommended by Bill Gates and included in GatesNotes "Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work." —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.

On the 100th anniversary of the pandemic of 1918, Jeremy Brown, veteran ER doctor and Director of Emergency Care Research at the National Institutes of Health, explores the troubling and complex history of the flu virus. He breaks down the current dialogue about the disease, explaining the controversy over vaccinations, antiviral drugs, and the federal government's role in preparing for pandemic outbreaks. Influenza is an enlightening and unnerving look at a deadly virus that has been around longer than people and may be for many more years before we are able to conquer it for good.

LOS ANGELES TIMES AND PUBLISHERS WEEKLY BESTSELLER • The powerful memoir of a young doctor and former college athlete diagnosed with a rare disease who spearheaded the search for a cure—and became a champion for a new approach to medical research. “A wonderful and moving chronicle of a doctor’s relentless pursuit, this book serves both patients and physicians in demystifying the science that lies behind medicine.”—Siddhartha Mukherjee, New York Times bestselling author of The Emperor of All Maladies and The Gene David Fajgenbaum, a former Georgetown quarterback, was nicknamed the Beast in medical school, where he was also known for his unmatched mental stamina. But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime. Miraculously, Fajgenbaum survived—only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself. More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide. Praise for Chasing My Cure “A page-turning chronicle of living, nearly dying, and discovering what it really means to be invincible in hope.”—Angela Duckworth, #1 New York Times bestselling author of Grit “[A] remarkable memoir . . . Fajgenbaum writes lucidly and movingly . . . Fajgenbaum’s stirring account of his illness will inspire readers.”—Publishers Weekly