This book formulates a relativistic theory of biology, challenging the common gene-centred view of organisms.

What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.

Money’s tight and Henry is lucky to have the job at Mr. Hairston’s grocery store. His parents are both lost in despair following the death of Henry’s older brother, and Henry is glad for the opportunity to feel like he’s helping. Saving to buy a marker for Eddie’s grave, Henry tries to ignore Mr. Hairston’s commentary about the customers. But Henry is shocked when he is told he’s being laid off. That is, unless he agrees to do one thing, one terrible thing.

This is a scientific and philosophical autobiography written around a collection of Denis Noble's most significant papers. It traces a remarkable journey from na ve reductionism to a rigorous systems approach to living systems. It is rigorous because Denis Noble was one of the first biologists to construct computer models of cells and organs of the body. His theoretical work is entirely mathematically based, with no room for ambiguity. Far from the denigration of the systems approach as holistic 'hand-waving', his work is now regarded by pharmaceutical companies and regulators as the gold standard of modelling in the development of new medication. Systems Biology is an idea in search of a definition. This book explains why this is true: it is an approach rather than a subject. Denis Noble's work is one of the clearest examples of the systems approach in practice since it reveals the nature of some of the forms of downward causation in multilevel analysis. The story will delight readers who like to see how scientific controversy is resolved, since many of the developments described in each chapter were highly controversial when they occurred.

Now in paperback. The bestselling author of The Willpower Instinct introduces a surprising science-based book that doesn't tell us why we should exercise but instead shows us how to fall in love with movement. Exercise is health-enhancing and life-extending, yet many of us feel it's a chore. But, as Kelly McGonigal reveals, it doesn't have to be. Movement can and should be a source of joy. Through her trademark blend of science and storytelling, McGonigal draws on insights from neuroscience, psychology, anthropology, and evolutionary biology, as well as memoirs, ethnographies, and philosophers. She shows how movement is intertwined with some of the most basic human joys, including self-expression, social connection, and mastery--and why it is a powerful antidote to the modern epidemics of depression, anxiety, and loneliness. McGonigal tells the stories of people who have found fulfillment and belonging through running, walking, dancing, swimming, weightlifting, and more, with examples that span the globe, from Tanzania, where one of the last hunter-gatherer tribes on the planet live, to a dance class at Juilliard for people with Parkinson's disease, to the streets of London, where volunteers combine fitness and community service, to races in the remote wilderness, where athletes push the limits of what a human can endure. Along the way, McGonigal paints a portrait of human nature that highlights our capacity for hope, cooperation, and self-transcendence. The result is a revolutionary narrative that goes beyond familiar arguments in favor of exercise, to illustrate why movement is integral to both our happiness and our humanity. Readers will learn what they can do in their own lives and communities to harness the power of movement to create happiness, meaning, and connection.

"This might be one of the month’s, if not the year’s, sweetest books — zaniest, too.” ―The Washington Post "A hilarious addition to the dogoir canon.” ―People "Perhaps the greatest love story ever told.” ―Refinery29 "The feel-good book the world needs." —PopSugar From one of the Internet's most original voices, a hilarious journey through the odd corners of obsessive dog ownership and the author's own infatuation with her perfect dog Peter. The author met Peter in the spring of 2017. He -- calm, puppy-eyed, with the heart of a poet and the soul of, also, a poet -- came to her first as a foster. He was unable to stay with his previously assigned foster for reasons that are none of your business, but which we will tell you were related to frequent urination. The rescue needed someone free of the sort of responsibilities that would force her to regularly leave the house for either work or socializing, and a writer was the natural choice. Thus began a love story for the ages. The Particulars of Peter is a funny exploration of the joy found in loving a dog so much it makes you feel like you're going to combust, and the author's potentially codependent relationship with her own sweet dog, Peter. Readers will follow Peter and his owner to Woofstock, "the largest outdoor festival for dogs in North America," and accompany them to lessons in Canine Freestyle, a sport where dogs perform a routine set to music, creating the illusion that they're dancing with their owners. From learning about Peter's DNA, to seeing if dogs can sense the presence of ghosts, The Particulars of Peter will give readers a smart, entertaining respite from the harsh world of humans into the funny little world of dogs. Readers will accompany this lovable duo through exciting trips, lessons, quiet moments of connection, and probably a failure or two. By fusing memoir and infotainment, The Particulars of Peter promises to refresh the perennially popular dog lit category in a scrumptiously bighearted barnstormer of a book.

The last century has seen radical social changes in Ireland, which have impacted all aspects of local life but none more so than traditional Irish music, an increasingly important identity marker both in Ireland and abroad. The author focuses on a small village in County Clare, which became a kind of pilgrimage site for those interested in experiencing traditional music. He begins by tracing its historical development from the days prior to the influx of visitors, through a period called "the Revival," in which traditional Irish music was revitalized and transformed, to the modern period, which is dominated by tourism. A large number of incomers, locally known as "blow-ins," have moved to the area, and the traditional Irish music is now largely performed and passed on by them. This fine-grained ethnographic study explores the commercialization of music and culture, the touristic consolidation and consumption of "place," and offers a critique of the trope of "authenticity," all in a setting of dramatic social change in which the movement of people is constant.