Cystic Fibrosis (CF) is a multisystem disease whose symptoms and signs involve the gastrointestinal tract (thus affecting nutritional status), endocrine system, reproductive system and the respiratory tract (nose, sinuses and lungs). Despite new treatments, the median survival for patients with CF is less than optimal, primarily due to complications of obstructive lung disease. Currently there are approximately 60,000-80,000 people worldwide with CF. The clinical manifestations of CF are caused by dysfunction of CFTR (cystic fibrosis transmembrane conductance regulator), a multifunctional cyclic-AMP regulated ion channel protein. Over time, there has been dramatic improvement in CF patient life expectancy, in large part related to earlier diagnosis (newborn screening), better understanding of molecular genetics and underlying pathophysiology, the integrated and highly specialized Cystic Fibrosis Foundation Accredited Care Centers, and development of a wide range of new treatments and therapies, some of which target the basic CFTR defect. This edition of Pediatric Clinics of North America will offer general pediatricians and family physicians, as well as subspecialists, an update of the extraordinary progress made in the understanding and treatment of Cystic Fibrosis.

In this issue of Pediatric Clinics of North America, guest editors Drs. Peter G. Szilagyi, Sharon G. Humiston, and Tamera Coyne-Beasley bring their considerable expertise to the topic of Vaccine Hesitancy. A growing problem even before the COVID-19 pandemic, vaccine hesitancy encompasses various factors involving both researchers and practitioners: transparency in research, scientific findings, and governmental programs; effective communication strategies; addressing and understanding cultural, psychosocial, spiritual, political, and cognitive factors; and a willingness to learn the root causes and concerns about vaccine hesitancy. In this issue, top experts address these topics to help you improve vaccine confidence with your patients. Contains 14 practice-oriented topics including COVID-19 vaccine hesitancy, vaccine hesitancy, trust, and culture; social media and vaccine hesitancy; optimizing your pediatric office for vaccine confidence; overcoming vaccine hesitancy using community-based efforts; and more. Provides in-depth clinical reviews on vaccine hesitancy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Pediatric Gastroenterology, An Issue of Pediatric Clinics of North America, E-Book

In collaboration with Consulting Editor, Dr. Bonita Stanton, Guest Editor Dr. Nelson L. Turcios has created a comprehensive issue on the multiple pulmonary symptoms associated with pediatric disease. In this issue of Pediatric Clinics of North America, expert authors have contributed clinical review articles that are current and timely. Articles are devoted to the following topics: Pulmonary Manifestations of Genetic Disorders in Children; Pulmonary Manifestations of Congenital Heart Disease in Children; Pulmonary Manifestations of Gastrointestinal, Pancreatic & Liver Diseases in Children; Pulmonary Manifestations of Hematologic and Oncologic Diseases in Children; Pulmonary Manifestations of Endocrine and Metabolic Diseases in Children; Pulmonary Manifestations of Immunosuppressive Diseases Other than HIV in Children; Pulmonary Manifestations of Human Immunodeficiency Virus (HIV) Infection in Children; Pulmonary Manifestations of Rheumatoid Diseases in Children; Pulmonary Manifestations of Systemic Vasculitis in Children; Pulmonary Manifestations of Neuromuscular Diseases in Children; Pulmonary Manifestations of Renal Disorders in Children; Pulmonary Manifestations of Parasitic Diseases in Children; Pulmonary Manifestations of Skin Disorders in Children; Adverse Environmental Exposure and Childhood Respiratory Health in Children; Functional Respiratory Disorders in Children; and Healthcare Inequalities in Pediatric Respiratory Diseases in Children. Pediatricians will come away with the clinical information they need to treat pulmonary conditions and manage outcomes in children with pediatric diseases.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Cystic Fibrosis (CF) is a multisystem disease whose symptoms and signs involve the gastrointestinal tract (thus affecting nutritional status), endocrine system, reproductive system and the respiratory tract (nose, sinuses and lungs). Despite new treatments, the median survival for patients with CF is less than optimal, primarily due to complications of obstructive lung disease. Currently there are approximately 60,000-80,000 people worldwide with CF. The clinical manifestations of CF are caused by dysfunction of CFTR (cystic fibrosis transmembrane conductance regulator), a multifunctional cyclic-AMP regulated ion channel protein. Over time, there has been dramatic improvement in CF patient life expectancy, in large part related to earlier diagnosis (newborn screening), better understanding of molecular genetics and underlying pathophysiology, the integrated and highly specialized Cystic Fibrosis Foundation Accredited Care Centers, and development of a wide range of new treatments and therapies, some of which target the basic CFTR defect. This edition of Pediatric Clinics of North America will offer general pediatricians and family physicians, as well as subspecialists, an update of the extraordinary progress made in the understanding and treatment of Cystic Fibrosis.

In this issue of Pediatric Clinics of North America, guest editors Drs. Huma Quraishi and Michael Chee bring their considerable expertise to the topic of Pediatric Otolaryngology. National health statistics indicate that disorders of the ear, nose, and throat are among the primary reasons children visit a physician, with ear infections ranking as the number one reason. This issue provides a comprehensive overview of otolaryngologic issues affecting children, providing the clinical information pediatricians need to make prompt diagnoses and facilitate positive patient outcomes. Contains 14 relevant, practice-oriented topics including otitis media and myringotomy tubes; congenital sensorineural hearing loss; tethered oral tissue/ankyloglossia/tongue and lip tie; adenotonsillectomy; pediatric obstructive sleep apnea syndrome; recurrent croup; and more. Provides in-depth clinical reviews on pediatric otolaryngology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.