A Glance at “Cutis Verticis Gyrate” a.k.a. “Bulldog” Scalp Syndrome. Cutis verticis gyrata (CVG), is a quaint benign cutaneous disorder that is characterized by convoluted folds and deep furrows of the scalp that mimic cerebral sulci and gyri. It was initially reported in the medical literature in 1837 by Alibert. In context with the subsequent classification by several researchers it is strived to describe the brief history for the enthusiastic medicos. In 1984, the classification system was further broken down into: · Primary essential, · Primary non-essential, and · Secondary CVG. Thus, an attempt has been made in this Booklet to review the Aetiology, Presentation, Workup, Management, Diagnosis etc. of cutis verticis gyrate along with plenty of illustrations for better understanding. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Due to its rapid development in recent years, hematopathology has become a very complicated discipline. The current development is mainly in two aspects: the new classification of lymphomas and leukemias and the new techniques. The Revised European-American Classification of Lymphoid Neoplasms (REAL classification) and the World Health Organization (WHO) classification of hematologic neoplasms require not only morphologic criteria but also immunophenotyping and molecular genetics for the diagnosis of hematologic tumors. Immunophenotyping is performed by either flow cytometry or immunohistochemistry. There are many new monoclonal antibodies and new equipments accumulated in recent years that make immunophenotyping more or more accurate and helpful. There are even more new techniques invented in recent years in the field of molecular genetics. In cytogenetics, the conventional karyotype is supplemented and partly replaced by the fluorescence in situ hybridization (FISH) technique. The current development of gene expression profiling is even more powerful in terms of subtyping the hematologic tumors, which may help guiding the treatment and predict the prognosis. In molecular biology, the tedious Southern blotting technique is largely replaced by polymerase chain reaction (PCR). The recent development in reverse-transcriptase PCR and quantitative PCR makes these techniques even more versatile. Because of these new developments, hematopathology has become too complicated to handle by a general pathologist. Many hospitals have to hire a newly trained hematopathologist to oversee peripheral blood, bone marrow and lymph node examinations. These young hematopathologists are geared to the new techniques, but most of them are inexperienced in morphology. No matter how well-trained a hematopathologist is, he or she still needs to see enough cases so that they can recognize the morphology and use the new techniques to substantiate the diagnosis. In other words, morphology is still the basis for the diagnosis of lymphomas and leukemias. Therefore, a good color atlas is the most helpful tool for these young hematopathologists and for the surgical pathologists who may encounter a few cases of hematologic tumors from time to time. In a busy daily practice, it is difficult to refer to a comprehensive hematologic textbook all the time. There are a few hematologic color atlases on the market to show the morphology of the normal blood cells and hematologic tumor cells. These books are helpful but not enough, because tumor cell morphology is variable from case to case and different kinds of tumor cells may look alike and need to be differentiated by other parameters. The best way to learn morphology is through the format of clinical case study. This format is also consistent with the daily practice of hematopathologists and with the pattern in all the specialty board examinations. Therefore, it is a good learning tool for the pathology residents, hematology fellows as well as medical students. This proposed book will present 83 clinical cases with clinical history, morphology of the original specimen and a list of differential diagnoses. This is followed by further testing with pictures to show the test results. At the end, a correct diagnosis is rendered with subsequent brief discussion on how the diagnosis is achieved. A few useful references will be cited and a table will be provided for differential diagnosis in some cases. The major emphasis is the provision of 500 color photos of peripheral blood smears, bone marrow aspirates, core biopsy, lymph node biopsy and biopsies of other solid organs that are involved with lymphomas and leukemias. Pictures of other diagnostic parameters, such as flow cytometric histograms, immunohistochemical stains, cytogenetic karyotypes, fluorescence in situ hybridization and polymerase chain reaction, will also be included. A comprehensive approach with consideration of clinical, morphologic, immunophenotypic and molecular genetic aspects is the best way to achieve a correct diagnosis. After reading this book, the reader will learn to make a diagnosis not only based on the morphology alone but also in conjunction with other parameters.

This classic text, one of the true anchors of our clinical genetics publishing program, covers over 700 different genetic syndromes involving the head and neck, and it has established itself as the definitive, comprehensive work on the subject. The discussion covers the phenotype spectrum, epidemiology, mode of inheritance, pathogenesis, and clinical profile of each condition, all of which is accompanied by a wealth of illustrations. The authors are recognized leaders in the field, and their vast knowledge and strong clinical judgment will help readers make sense of this complex and burgeoning field. Dr. Gorlin retires as editor in this edition and co-editor Raoul Hennekam takes over. Dr. Hennekam is regarded as one of the top dysmorphologists--and indeed one of the top clinical geneticists--in the world. Judith Allanson is new to the book but is a veteran OUP author and a widely respected geneticist, and Ian Krantz at Penn is a rising star in the field. Dr. Gorlin's name has always been closely associated with the book, and it has now become part of the title. As in all fields of genetics, there has been an explosion in the genetics of dysmorphology syndromes, and the author has undertaken a complete updating of all chapters in light of the discoveries of the Human Genome Project and other ongoing advances, with some chapters requiring complete rewriting. Additional material has been added both in terms of new syndromes and in updating information on existing syndromes. The book will appeal to clinical geneticists, pediatricians, neurologists, head and neck surgeons, otolarynologists, and dentists. The 4th edition, which published in 2001, has sold 2,600 copies.

Cutaneous lymphomas are one of the most difficult but also most interest ing and challenging areas in clinical and experimental dermatology and pathology. While even "routine" cases can pose diagnostic difficulties be yond those associated with similar lymphomas in lymph nodes, cutaneous lymphomas often have unusual features that pose a wide spectrum of ques tions concerning diagnosis, classification, pathogenesis and therapy. This book is an unique collection of unusual cases of cutaneous T-cell, B-cell and NK-cell lymphomas, leukemias and other disorders related to cutaneous lymphoma, presented in a concise format. The authors have pro vided excellent illustrations and precise descriptions with short comments and reliable references. All of the authors are highly regarded experts in the field of cutaneous lymphomas and lymphoproliferative diseases and their contributions guarantee the high quality performance of this book. The limitations of their perceptions of these cases reflect the limits of our knowledge in 2001, not the limitations of their expertise. Zurich and San Francisco, GUNTER BURG February 2001 PHILIP LEBoIT I Table of Contents 1 Cutaneous T-cell Lymphoma (an) • 1.1 Mycosis Fungoides and Related Disorders . . . . . . . . . . . 2 . . . . . . . .

A comprehensive review of all the vascular proliferations involving the skin and subcutaneous tissue, including recently described disease entities. Superbly illustrated with both clinical and histopathologic photographs, the book moves from a proposed new system of classification and nomenclature for vascular neoplasms, to a full discussion of benign and malignant proliferations, including hamartomas, benign neoplasms, malignant neoplasms, and several related newly reported diseases. The authors describe in-depth the clinical and morphologic aspects of each entity and detail their clinicopathologic correlation, differential diagnosis, prognosis, and therapy.

Over a decade has passed since the original edition of The Clinician's Guide to Dermatologic Differential Diagnosis first came out. This massive two volume, second edition undertaking features over 4,000 new photographs of rare and puzzingly symptoms, 98 new chapters, and presents a complete update on all references and new findings since the original publication. This two volume set is designed to assist in the diagnosis of skin disease by presenting a unique and comprehensive approach to differential diagnosis. Organized alphabetically by physical finding each book in the set is meticulously put together for utility and usability. Volume 1 features a comprehensive list of the variety of physical findings a patient might have. It is the text of the work. Volume 2 serves as the atlas with which to cross reference a physical finding. It includes over 10,000 patient photos and strives to feature the rarer, more difficult to encounter pictures to arm the reader with knowledge beyond the basic. Created purely with the reader in mind, The Clinician's Guide to Dermatologic Differential Diagnosis, 2nd Edition strives to enhance the learning and teaching of differential diagnosis within dermatology. These texts are for the patient that defies diagnosis, going through checklists of diseases ensures that no clue is missed in aiding the patient. The sincere hope is that these companion volumes will be helpful in all clinical setting from medical clinic and other specialty clinics to the Dermatology clinic, from medical students to attendings, and from the nurses to the physicians assistants, whether in the academic setting or in the community environment anywhere in the world.