This latest volume in the Current Topics in Medical Mycology series brings together internationally recognized researchers to summarize current topics of interest to medical mycologists and other scientists who are working in microbiology and immunology. A blend of contemporary, authoritative reviews and summaries of new advancements and future directions, Volume 3 aims to promote the interdisciplinary use of medically important fungi in pathogenesis, epidemiology, mycotoxins, taxonomy, and other areas where basic, applied, and clinical science are used.

This summary of rapid advances in the field of medical mycology is tailored to the needs of mycologists, physicians, and others using fungi as model systems.

Current Topics in Medical Mycology, which is a new annual series published by Springer-Verlag, is intended to summarize current topics in medical mycology for medical mycologists and other scientists who are work- ing in microbiology and immunology. Topics to be in- cluded in each year's volume will serve as contemporary reviews, summaries of current advancements and future directions, and mechanisms to enhance the interdiscipli- nary use of medically important fungi in the areas of pathogenesis, epidemiology, mycotoxins, taxonomy, and other areas where basic, applied, and clinical science are used. Michael R. McGinnis Contents ix Contributors 1 Pathology of the Mycoses in Patients with the Acquired Immunodeficiency Syndrome (AIDS) FRANCIS W. CHANDLER 1 Composition and Structure of Yeast Cell 2 Walls 24 GRAHAM H. FLEET 3 Animal Models for Candidiasis M. NEAL GUENTZEL, GARRY T. COLE, and 57 LEODOCIA M. POPE 4 Dermatophyte Antigens and Cell-Mediated Immunity in Dermatophytosis 117 TAAVIKAAMAN 5 Natural Cell-Mediated Resistance Against Cryptococcus neoformans: A Possible Role for Natural Killer (NK) Cells J UNEANN W. M URPHY 135 6 Biotyping of Medically Important Fungi FRANK C.ODDS 155 7 Characterization of Protein and Mannan Polysaccharide Antigens of Yeasts, Moulds, and Actinomycetes ERROL REISS, MILTON HUPPERT, and ROBERT CHERNIAK 172 Contents viii The Changing Epidemiology and Emerging 8 Patterns of Dermatophyte Species 208 JOHN WILLARD RIPPON 9 Paracoccidioides brasiliensis: Cell Wall Glucans, Pathogenicity, and Dimorphism GIOCONDA SAN-BLAS 235 10 The Role of Zinc in Candida Dimorphism 258 DAvID R. SOLL 11 Killer Yeasts REED B.

The identification of medically important fungi has been an important area of study that warrants further extensive research. The use oftraditional and molecular methods of identification, provides new insights into differentiation of species and ultimately the line of treatment can be determined. This book incorporates a diverse group of medically

Infections caused by fungi have recently attracted the attention of both clinicians and basic researchers given the heavy burden they represent for any health system. The mortality and morbidity rates associated to mycosis are progressively rising simply because some of these diseases are still neglected by health-care workers and due to the changing sensitivity to antifungal drugs displayed by these organisms. In this book, both researchers and clinicians working in the medical mycology field explore the most recent literature about specific mycosis; placing in one concise chapter thoroughly revisions of the current knowledge on virulence factors, recognition by immune cells, immunoevasion, epidemiology, new diagnosis trends and therapeutics. This book is recommended to researchers, physicians and students interested in medical mycology.

Medical mycology deals with those infections in humans, and animals resulting from pathogenic fungi. As a separate discipline, the concepts, methods, diagnosis, and treatment of fungal diseases of humans are specific. Incorporating the very latest information concerning this area of vital interest to research and clinical microbiologists,Fundamental Medical Mycology balances clinical and laboratory knowledge to provide clinical laboratory scientists, medical students, interns, residents, and fellows with in-depth coverage of each fungal disease and its etiologic agents from both the laboratory and clinical perspective. Richly illustrated throughout, the book includes numerous case presentations.

The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.