A teenager is found dead in his motel room, the cause of death: millipede poison...Now crime scene investigator Gil Grissom must aid CSI's Nick Stokes and Riley Adams against a serial killer whose knowledge of entomology rivals his own -- a brutal murderer who is not only using insects as the tools of destruction, but actually modeling the attacks after their behavior.... In the meantime, CSIs Catherine Willows and Greg Sanders must investigate a bizarre death, where the victim had gotten mixed up with two very different groups of people -- one involved in using and dealing crystal meth, the other an avant-garde group of artists -- a collision of subcultures where everyone is a suspect and nothing is as it seems....

The machinations of a new supervisor may have altered Gil Grissom's team of skillful CSIs, as Catherine Willows, Nick Stokes, and Warrick Brown are reassigned from the graveyard shift to the swing shift. That doesn't mean, however, that their paths will never cross. During the course of their separate investigations, the teams must unite again to investigate two distinct murders -- atrocities that are oddly aligned as they share much of the same collective evidence. Despite the different M.O.s, the CSIs are uncovering two wildly imperfect crimes that could possibly add up to an almost perfect one...

A retired judge has been found brutally murdered on the outskirts of Las Vegas, complete with a macabre yet masterfully intricate tattoo on his face . . . the third seemingly random victim of the mysterious kidnapper dubbed by law enforcement as the “Tattoo Man.” The judge wasn’t the first person to have been abducted, drugged, and permanently altered with tattoos and body modification . . . but he was the first to wind up dead. At the same time, several other deceased are turning up all over Sin City with their body art mercilessly removed—and the timing would seem to suggest to those in authority that all of these crimes are somehow related. But Las Vegas’s top crime scene investigators—Catherine Willows, Ray Langston, Nick Stokes, Sara Sidle, and Greg Sanders—aren’t jumping to any conclusions, as they attempt to connect the dots by entering the secretive and tight-knit body art community—one that is intensely wary of outsiders. . . .

The Las Vegas team of investigators has its hands full following a free-spending night at an exclusive nightclub which leaves the chairman of the Cloud Mountain Paiute Tribe dead. Already surrounded by controversy, the victim had a message scrawled in his own blood at the scene that would indicate a crime of revenge—and members of the chairman’s inner circle aren’t talking, which leads to a vicious cycle of violence and murder.... ?

It’s a hot, early autumn evening in the small resort town of Mount Charleston, NV, where six firefighters are battling a massive blaze that threatens expensive homes . . . a blaze that will cost them their lives. Initially, the police determine that the fire was human-started, and the state wants to prosecute to the fullest extent of the law with six counts of homicide. Now the team of Sin City’s finest criminologists, led by Catherine Willows, are assigned to work a crime scene far from the glittering lights and 24/7 spectacle of the Las Vegas Strip, and soon find much more than they bargained for. . . . Meanwhile, Ray Langston and Nick Stokes are called to a crime scene where a dog has taken a key piece of evidence—a severed human hand—under a suburban home’s crawl space. What’s even more disturbing is that it’s not the first severed hand that’s turned up lately—there have been four other incidents around Las Vegas over the past twelve months. . . .

A lavish penthouse party on top of a Vegas hotel and casino plays host to a bizarre set-up to murder in which a security guard is trapped and killed in a private elevator—and the body soon vanishes . . . leading crime scene investigators Nick Stokes and Greg Sanders straight to an uncanny circus troupe with deadly connections to none other than the Russian mafia. In the meantime, Ray Langston and Catherine Willows are called to a psychiatric facility where two patients have just escaped after attacking an orderly. One of the escaped patients, an Iraq war veteran, managed to smuggle in a military-grade nerve gas, inducing realistic and shared three-dimensional illusions and hallucinations . . . and Ray and Catherine must race against time in order to find two very dangerous individuals now roaming freely on the streets of Las Vegas. . . .