Crystallographic Studies on 2-oxoglutarate Dependent Oxygenases
Title | Crystallographic Studies on 2-oxoglutarate Dependent Oxygenases PDF eBook |
Author | Wei Shen Aik |
Publisher | |
Pages | |
Release | 2014 |
Genre | |
ISBN |
2-Oxoglutarate-Dependent Oxygenases
Title | 2-Oxoglutarate-Dependent Oxygenases PDF eBook |
Author | Christopher Schofield |
Publisher | Royal Society of Chemistry |
Pages | 508 |
Release | 2015-04-23 |
Genre | Science |
ISBN | 1782621954 |
Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
Mechanistic Studies on 2-oxoglutarate Dependent Oxygenases
Title | Mechanistic Studies on 2-oxoglutarate Dependent Oxygenases PDF eBook |
Author | Andrea Szollossi |
Publisher | |
Pages | |
Release | 2012 |
Genre | |
ISBN |
Functional and Inhibition Studies on 2-oxoglutarate-dependent Oxygenases
Title | Functional and Inhibition Studies on 2-oxoglutarate-dependent Oxygenases PDF eBook |
Author | Armin Thalhammer |
Publisher | |
Pages | |
Release | 2012 |
Genre | |
ISBN |
Molecular and Cellular Studies on the 2-oxoglutarate-dependent Oxygenase MINA53
Title | Molecular and Cellular Studies on the 2-oxoglutarate-dependent Oxygenase MINA53 PDF eBook |
Author | Eline Hendrix |
Publisher | |
Pages | 0 |
Release | 2021 |
Genre | |
ISBN |
Kinetic and Mechanistic Studies of Oxygen Sensing Fe(II)/2-oxoglutarate Dependent Oxygenases
Title | Kinetic and Mechanistic Studies of Oxygen Sensing Fe(II)/2-oxoglutarate Dependent Oxygenases PDF eBook |
Author | Hanna Tarhonskaya |
Publisher | |
Pages | |
Release | 2014 |
Genre | |
ISBN |
Nitric Oxide, Cell Signaling, and Gene Expression
Title | Nitric Oxide, Cell Signaling, and Gene Expression PDF eBook |
Author | Santiago Lamas |
Publisher | CRC Press |
Pages | 453 |
Release | 2005-11-01 |
Genre | Science |
ISBN | 1420027166 |
Since the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds, and doctors were prescribing it to relieve angina, scientists have been exploring the incredible and often baffling behavior of nitric oxide. In the 1980s, researchers discovered that nitric oxide had the capacity to regulate vascular tone through cyclic GMP,