Practical and easy-to-use reference progresses from simple to advanced topics, covering, among other topics, renewal theory, Markov chains, Poisson approximation, ergodicity, and Strassen's theorem. 1992 edition.

How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Carolynn Kingyens dazzles once again in a second collection defined by her distinctive insights and gift for revealing detail. In Coupling, she examines the tapestry of human pairings in all of their fragility, resilience and mystery, taking readers on a staff ride through hills and dales of romance and surprise, mountains of hope and valleys of regret. As original as Neruda and as wise as Mary Oliver, Kingyens understands how to capture the moment like no other contemporary poet. These are gentle narrative poems as honest as they are true. -Jacob M. Appel, author of The Cynic in Extremis Coupling is a masterful book of poems dealing with modern life and its complexities. From the pandemic to relationships, the poet presents a powerful landscape of the day to day. I thought of you somewhere being wind..., and only white, refrigerated / trucks and the vultures / circling above- / this time, it's no mirage. Kingyens holds up the hard truths reminding us it's no mirage. Coupling is a harvest for the taking. -Gloria Mindock, author of Ash, editor of Červená Barva Press Carolynn Kingyens is a master of communicating how it feels to move through our society in a woman's body. Things happen to you, and around you, and you are made complicit-forced to show empathy, forced to take on the burdens of others. In writing about life during pandemic times, the poet says, People are dying alone. This attention to public grief speaks volumes about the poet's compassion despite battles with her own personal demons. There is a loneliness in many of Kingyens' poems. The poet reveals to the reader how internal battles are fought and overcome, but not necessarily won. In Coupling, Kingyens offers cautionary tales about sex, mental health, death, and the complex role of religion for both self and society. -Mark Danowsky, Editor-in-Chief, ONE ART: a journal of poetry

"Second Edition provides new material on coupling ratings, general purpose couplings versus special purpose couplings, retrofitting of lubricated couplings to nonlubricated couplings, torsional damping couplings, torquemeter couplings, and more."

This handbook and ready reference brings together all significant issues of practical importance in selected topics discussing recent significant achievements for interested readers in one single volume. While covering homogeneous and heterogeneous catalysis, the text is unique in focusing on such important aspects as using different reaction media, microwave techniques or catalyst recycling. It also provides a comprehensive treatment of key issues of modern-day coupling reactions having emerged and matured in recent years and emphasizes those topics that show potential for future development, such as continuous flow systems, water as a reaction medium, and catalyst immobilization, among others. With its inclusion of large-scale applications in the pharmaceutical industry, this will equally be of great interest to industrial chemists. From the contents * Palladium-Catalyzed Cross-Coupling Reactions - A General Introduction * High-turnover Heterogeneous Palladium Catalysts in Coupling Reactions: the Case of Pd Loaded on Dealuminated Y Zeolites Palladium-Catalyzed Coupling Reactions with Magnetically Separable Nanocatalysts * The Use of Ordered Porous Solids as Support Materials in Palladium-Catalyzed Cross-Coupling Reactions * Coupling Reactions Induced by Polymer-Supported Catalysts * Coupling Reactions in Ionic Liquids * Cross-Coupling Reactions in Aqueous Media * Microwave-Assisted Synthesis in C-C and C-Heteroatom Coupling Reactions * Catalyst Recycling in Palladium-Catalyzed Carbon-Carbon Coupling Reactions * Nature of the True Catalytic Species in Carbon-Carbon Coupling Reactions with * Heterogeneous Palladium Precatalysts * Coupling Reactions in Continuous Flow Systems * Large-Scale Applications of Palladium-Catalyzed Couplings in the Pharmaceutical Industry

Conscious Coupling, Saving Relationships from the perspectives of two divorce mediators wages war on saving relationships and ultimately saving families. Dana and Don, two divorce mediators and licenses couple's and family therapist offer insight from the mediator's/counselor's perspective directly from real cases they have both counseled before and after divorce and during separation negotiations. This book amplifies the "root cause analysis" within couples that without recognition or restoration, Dana and Don believe that any relationship will ultimately dissolve. Conscious coupling honestly addresses the true bases of relationship fulfillment as well as its ultimate demise. Each author writes separately his and her personal and professional experiences on each chapter. Such as, the future of relationship, money and sex values, infidelity, family of origin, extended family, social influences, as well as modern marriage, parenting, and the most common relational traits as compatibility, co-habitation and communications. This is not a psychoanalytical or legal text book, this is a true to life, based on real cases, that young couples who haven't married yet or couples who are already married need to be aware of if they intend on maintaining a happy and satisfying and blissful existence together. There is no other book out there, that divorce mediators have written, to save families.

Presents archival anecdotes and analyses of coupling problems experienced by the X-series, Century series, and Space Shuttle aircraft. The three catastrophic sequential coupling modes of the X-2 airplane and the two simultaneous unstable modes of the X-15 and Space Shuttle aircraft are discussed. In addition, the most complex of the coupling interactions, inertia roll coupling, is discussed for the X-2, X-3, F-100A, and YF-102 aircraft. The mechanics of gyroscopics, centrifugal effect, and resonance in coupling dynamics are described. The coupling modes discussed are interacting multiple degrees of freedom of inertial and aerodynamic forces and moments. Various solutions for coupling instabilities are discussed.