Focusing on new biophysical and analytical methods that can assess lipid status and the improvement of skin condition, this reference provides essential quantitative information on the interaction of topically applied lipids with skin barrier lipids. Containing contributions from internationally recognized specialists and over 1000 references, drawings, photographs, and tables, it explores how different lipid varieties function in cosmetic formulations and on the skin. Coverage includes the chemistry, structure, and biological functions of skin lipids and their interaction with the lipids formulated into skin and hair care preparations.

Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.

Back for a new edition, Zoe Draelos' outstanding resource to cosmetic dermatology again provides a highly-illustrated, clinical guide to the full range of cosmetic skin treatments. Bringing together experts from research, industry, surgery and practice, it is structured in four distinct parts for easy navigation by the busy clinician: Basic Concepts - giving an overview of the physiology pertinent to cosmetic dermatology and the delivery systems by which treatments can take effect; Hygiene Products - evaluating cleansing and moisturising products; Adornment - looking at aesthetic techniques such as cosmetics, nail protheses and hair treatment; Antiaging - ie, injectables, resurfacing and skin contouring techniques, and the rapidly growing area of Cosmeceuticals. With over 300 high-quality images and key summary boxes throughout, this new edition incorporates the newest procedural innovations in this rapidly developing field. Perfect for all dermatologists, especially those specialising in cosmetic dermatology and whether hospital-based or in private practice, it provides the complete cosmetic regimen for your patients and will be an indispensable tool to consult over and over again.

A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatiti

This book addresses the application of nanotechnology to cosmetics. Edited by three respected experts in the field, the book begins with a general overview of the science behind cosmetics and skin care today, and of the status quo of nanotechnology in cosmetics. Subsequent chapters provide detailed information on the different nanoparticles currently used in cosmetics; the production and characterization of nanoparticles and nanocosmetics; and regulatory, safety and commercialization aspects. Given its scope, the book offers an indispensable guide for scientists in academia and industry, technicians and students, as well as a useful resource for decision-makers in the field and consumer organizations. Chapter 6 of this book is available open access under a CC BY 4.0 licence at link.springer.com.

Lipids and Skin Health is the first effort to summarize and review the studies, ideas, and research that link lipid metabolism to the largest organ of our body, the skin. The book covers the fundamental biology of the skin, and the major involvement of the transcriptional factors that govern lipid synthesis and the bioactive lipids in this intriguing organ. All layers of skin are presented, as well as their relevant lipids from the epidermis to dermis and even to the hypodermis. The important and unique-to-skin biological pathways are laid out, with a special focus on the various models that demonstrate the essential role of lipid synthesis in skin pathophysiology. The use of lipids in the cosmetic industry is emphasized, and last but not least the involvement of lipids in the clinical setting is also discussed. This book will appeal to healthcare professionals, researchers and dermatology professionals, and will help them to brainstorm new products and opportunities that will target the emerging importance of lipid metabolism in skin for acne, aging, and healthy skin. Apostolos Pappas, Ph.D., is a professional member of the Institute of Food Technology. He started his professional career as a research biochemist in the Skin Research Center of Johnson & Johnson and later served as a group leader at Munich Biotech, where he worked on cancer research. Thereafter he returned to Johnson & Johnson, where he is currently a Research Manager and Fellow focusing on lipid metabolism research. He has authored numerous scientific publications, patent applications, and books.

The concept of expressing acidity as the negative logarithm of the hydrogen ion concentration was defined and termed pH in the beginning of the 20th century. The general usefulness of the pH concept for life science was recognized and later gained importance to analytical research. Reports on results of pH measurements from living skin established the term acid mantle - the skin's own protective shield that maintains a naturally acid pH. It is invisible to the eye but crucial to the overall wellbeing of skin. Chronic alkalization can throw this acid mantle out of balance, leading to inflammation, dermatitis, and atopic skin diseases. It is therefore no surprise, that skin pH shifts have been observed in various skin pathologies. It is also obvious that the pH in topically applied preparations may play an important role. Optimal pH and buffer capacity within topical preparations not only support stability of active ingredients and auxiliary materials, but may also increase absorption of the non-ionized species of an acidic or a basic active ingredient. They may even open up opportunities to modify and "correct" skin pH and hence accelerate barrier recovery and maintain or enhance barrier integrity. Further efforts are needed to standardize and improve pH measurements in biological media or pharmaceutical/cosmetic vehicles to increase and ensure quality, comparability, and relevance of research data. In this volume, we present a unique collection of papers that address past, present and future issues of the pH of healthy and diseased skin. It is hoped that this collection will foster future efforts in clinical and experimental skin research.