Bacterial Vaccines provides information dealing with vaccination of man against bacterial diseases. This book emphasizes the description, composition, production, and control of the vaccines, as well as vaccine benefits and drawbacks. Organized into 14 chapters, this book contains a description of the etiological agent, particularly with respect to its antigenic composition, and also of the pathogenesis of the disease and the immune mechanisms acting against it. The chapters are separated according to the disease they describe, which include diphtheria, tetanus, pertussis, cholera, typhoid fev ...

One of the most important organisms in biotechnology, Corynebacterium glutamicum is currently used to produce 2 million tons of amino acids per year for a rapidly expanding market. Until now, research and information have been scattered among individual papers which are often difficult to locate in a timely manner. As the first complete comp

This volume brings together the expertise and enthusiasm of today's leading experts to provide a description of the current state-of-the-art molecular biology toolbox available for Corynebacterium research, including global analyses techniques such as comparative genomics, transcriptome, proteome and metabolome analysis as well as the most recent knowledge on Corynebacterium promoter structures and vector systems. Furthermore, topics such as regulatory networks controlling carbon, nitrogen, phosphorus, sulphur and iron metabolism, cell wall structure, proteolysis and environmental stress respo.

Bacterial Pathogens and their Virulence Factors contains a detailed description of 32 major bacterial pathogens that affect human health and their associated virulence determinants. Chapter 1 gives an overview of the different types and classes of general virulence factors involved in host cell adherence and invasion, dissemination within the host, host cell damage, and evasion of host defense systems, as well as mechanisms by which these virulence factors are regulated. Chapters 2 through 33 give concise descriptions of the disease states associated with the 32 bacterial genera and their major pathogenic species, along with an in-depth description of the individual virulence factors that have been found to be functionally involved in pathogenicity. A detailed bibliography derived from primary literature and review articles accompanies each of these chapters, allowing the reader to delve more deeply into individual pathogens and their virulence determinants. Chapter 34 discusses the exciting possibilities and initial successes of using detailed information on a pathogen’s virulence toolkit to design new therapeutics aimed at specific virulence traits.

The latest volume in the Advanced Biotechnology series provides an overview of the main production hosts and platform organisms used today as well as promising future cell factories in a two volume book. Alongside describing tools for genetic and metabolic engineering for strain improvement, the authors also impart topical information on computational tools, safety aspects and industrial-scale production. Following an introduction to general concepts, historical developments and future technologies, the text goes on to cover multi-purpose bacterial cell factories, including those organisms that exploit anaerobic biosynthetic power. Further chapters deal with microbes used for the production of high-value natural compounds and those obtained from alternative raw material sources, concluding with eukaryotic workhorses.