Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

The perfect hands-on reference, Gray's Clinical Photographic Dissector of the Human Body, 3rd Edition, is a practical resource in the anatomy lab, on surgical rotations, during clerkship and residency and beyond! This fully revised third edition uses a unique, step-by-step presentation of full-color cadaveric photographs to orient you more quickly in the anatomy lab, and points out the clinical relevance of each structure and every dissection. Each photograph depicts clearly labeled anatomical structures, including muscles, bones, nerves, blood vessels, and organs—making this one-of-a-kind resource ideal for preparing for laboratory sessions and as a useful reference during dissections. - Contains nearly 1,100 full-color photographs for comparison to the cadavers you study, helping you become more proficient and confident in your understanding of the intricacies of the human body. - Guides you through each dissection step-by-step, using a unique, real-world photographic presentation. - Includes complementary high-quality schematic drawings throughout to help orientate you and aid understanding. - Contains superb corresponding Gray's illustrations to add clarity to key anatomical structures. - Helps you easily relate anatomical structures to clinical conditions and procedures. - Features new explanatory videos of human cadaveric dissection for each chapter. - Depicts the pertinent anatomy for more than 30 common clinical procedures such as prosthetic hip replacements, intravenous catheters, lumbar puncture, and knee joint aspiration, including where to make the relevant incisions. - Reflects the same level of accuracy and thoroughness that has made the Gray's 'family' of products the most trusted learning resources in anatomy. - Prepared by an expert author team—highly experienced educators and leading authorities in clinical anatomy. The Evolve Instructor site with downloadable images is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.

This volume brings together recent research findings on sign language and primatology and offers a novel approach to comparative language acquisition. The contributors are anthropologists, psychologists, linguists, psycholinguists, and manual language experts. They present a lucid account of what sign language is in relation to oral language, and o