Research was performed to determine total costs (construction and road user costs) and safety impacts associated with traffic control through work zones on rural four-lane, divided highways using single lane closure (SLC) versus two-lane, two-way traffic operations (TLTWO). An informational guide for use in selecting cost-effective traffic control strategies for proposed construction projects was also prepared. Construction data were collected from 51 construction projects in 11 States, and traffic capacity delay studies were conducted at 25 projects in 10 States. Guidelines are presented in this report for selection of the best traffic control alternative between SLC and TLTWO. A simplified procedure to estimate road user costs for SLC and TLTWO traffic control strategies is also included. This guide is Volume II of a two-volume series. Volume I (FHWA-RD-89-209) is the final report.