With no choice but to face her destiny straight on, Kaia is determined to end the curse—no matter the personal cost. Sacrificing her own wants and desires, she turns herself over to the evil king, Morlet. Together, they seek to discover the catalyst for the events that started it all over a hundred years ago. The path she embarks on tests her skills, her willpower, and her heart. Facing the darkest truth inside of her, she makes a choice that not only has unspeakable consequences, but also changes her life and the future of the kingdom forever.

This rereading of the history of American westward expansion examines the destruction of Native American cultures as a successful campaign of "counterinsurgency." Paramilitary figures such as Daniel Boone and Davy Crockett "opened the West" and frontiersmen infiltrated the enemy, learning Indian tactics and launching "search and destroy" missions. Conventional military force was a key component but the interchange between militia, regular soldiers, volunteers and frontiersmen underscores the complexity of the conflict and the implementing of a "peace policy." The campaign's outcome rested as much on the civilian population's economic imperatives as any military action. The success of this three-century war of attrition was unparalleled but ultimately saw the victors question the morality of their own actions.

Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. - Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities - Showcases recent advancements in RAS research under one comprehensive volume - Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research

When faced with global instability and economic uncertainty, it is tempting for states to react by closing borders, hoarding wealth and solidifying power. We have seen it at various times in Japan, France and Italy and now it is infecting much of Europe and America, as the vote for Brexit in the UK has vividly shown. This insularity, together with increased inequality of income and wealth, threatens the future role of the West as a font of stability, prosperity and security. Part of the problem is that the principles of liberal democracy upon which the success of the West has been built have been suborned, with special interest groups such as bankers accruing too much power and too great a share of the economic cake. So how is this threat to be countered? States such as Sweden in the 1990s, California at different times or Britain under Thatcher all halted stagnation by clearing away the powers of interest groups and restoring their societies' ability to evolve. To survive, the West needs to be porous, open and flexible. From reinventing welfare systems to redefining the working age, from reimagining education to embracing automation, Emmott lays out the changes the West must make to revive itself in the moment and avoid a deathly rigid future.