Adverse medication reactions account for up to 7,000 deaths annually in the United States. In today's era of polypharmacy, busy clinicians - especially those who practice in medical/surgical settings - must be able to quickly find and even anticipate psychiatric drug interactions.

An understanding of drug interactions has become essential to the practice of medicine. Since publication of the first edition of this Concise Guide in 2001, our increasing pharmacopoeia—coupled with prolonged human life spans—has made polypharmacy commonplace. Like the first edition of this unique pocket reference, the Second Edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues. This exceptionally practical guide is divided into four parts: 1. An easy-to-read, succinct review of pharmacology, written with clinicians in mind, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions. 2. Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes highlighted with newly expanded tables and study cases. 3. A section unique to this book on drug interactions by medical specialty, with drug tables arranged by how they are used in specialties such as gynecology, infectious diseases, internal medicine, neurology, oncology, psychiatry, and pain medicine. 4. Chapters on practical matters: prescribing guidelines, how to identify drug interaction patterns, strategies for reviewing the current literature, and medicolegal concerns. Enhanced by detailed descriptions and clinically based explanations, and complemented by a unique pocket guide to the most common and potent inhibitors and inducers of drug metabolism, this updated concise "how-to" guide will prove indispensable for busy students, teachers, and practitioners in all medically specialties.

This remarkable volume of case vignettes was written to complement the principles detailed in the comprehensive work "Concise Guide to Drug Interaction Principles for Medical Practice: Cytochrome P450s, UGTs, P-Glycoproteins," Second Edition, published by American Psychiatric Publishing, Inc. Each case is thoroughly referenced and depicts real clinical events. Many are direct narrations from patients of the author or his colleagues, with identifiers subtly altered to ensure confidentiality. Others are constructed around well-known, accepted, and multiply-verified interactions. The introductory chapter reviews core concepts and summarizes the P450 system, phase II glucuronidation and P-glycoproteins. Subsequent chapters are organized by the nature of the metabolic processes that account for the depicted drug interactions. At the end of this volume is a revealing self-assessment test case so readers can evaluate their progress in diagnosing drug interactions. Thoroughly indexed and referenced, with three indispensable appendices of tables for quick reference to the P450 system, UGTs, and P-glycoproteins, the case vignettes in this exceptional work illustrate interactions with both psychoactive agents and drugs from other branches of medicine. As such, this essential companion to more in-depth analyses of the P450 system will find an immediate audience among not only psychiatrists but also a wide range of medical specialists and generalists, as well as those who are in any way acquainted with the mental health field.

Topics covered in this volume include: an introduction to the P450 system and basic pharmacology; an introduction to P450 and to this concise guide; basic Pharmacology; metabolic variability - inhibition, induction, and pharmacogenetics; P450 Enzymes; 2D6; 3A4; 1A2; 2C9; 2C19; 2E1; guidelines; how to retrieve and review the literature.

Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.

This book covers the relevant aspects of cytochromes P450 for understanding their structure, function and mechanisms of action, such as physicochemical characterization methods, redox interactions, evolution and genetics, experimental and theoretical models, induction, inhibition and metabolism.

This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data. Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology.