Computational Retinal Image Analysis: Tools, Applications and Perspectives gives an overview of contemporary retinal image analysis (RIA) in the context of healthcare informatics and artificial intelligence. Specifically, it provides a history of the field, the clinical motivation for RIA, technical foundations (image acquisition modalities, instruments), computational techniques for essential operations, lesion detection (e.g. optic disc in glaucoma, microaneurysms in diabetes) and validation, as well as insights into current investigations drawing from artificial intelligence and big data. This comprehensive reference is ideal for researchers and graduate students in retinal image analysis, computational ophthalmology, artificial intelligence, biomedical engineering, health informatics, and more.

Computational Retinal Image Analysis: Tools, Applications and Perspectives gives an overview of contemporary retinal image analysis (RIA) in the context of healthcare informatics and artificial intelligence. Specifically, it provides a history of the field, the clinical motivation for RIA, technical foundations (image acquisition modalities, instruments), computational techniques for essential operations, lesion detection (e.g. optic disc in glaucoma, microaneurysms in diabetes) and validation, as well as insights into current investigations drawing from artificial intelligence and big data. This comprehensive reference is ideal for researchers and graduate students in retinal image analysis, computational ophthalmology, artificial intelligence, biomedical engineering, health informatics, and more. - Provides a unique, well-structured and integrated overview of retinal image analysis - Gives insights into future areas, such as large-scale screening programs, precision medicine, and computer-assisted eye care - Includes plans and aspirations of companies and professional bodies

Many approaches have been proposed to solve the problem of finding the optic flow field of an image sequence. Three major classes of optic flow computation techniques can discriminated (see for a good overview Beauchemin and Barron IBeauchemin19951): gradient based (or differential) methods; phase based (or frequency domain) methods; correlation based (or area) methods; feature point (or sparse data) tracking methods; In this chapter we compute the optic flow as a dense optic flow field with a multi scale differential method. The method, originally proposed by Florack and Nielsen [Florack1998a] is known as the Multiscale Optic Flow Constrain Equation (MOFCE). This is a scale space version of the well known computer vision implementation of the optic flow constraint equation, as originally proposed by Horn and Schunck [Horn1981]. This scale space variation, as usual, consists of the introduction of the aperture of the observation in the process. The application to stereo has been described by Maas et al. [Maas 1995a, Maas 1996a]. Of course, difficulties arise when structure emerges or disappears, such as with occlusion, cloud formation etc. Then knowledge is needed about the processes and objects involved. In this chapter we focus on the scale space approach to the local measurement of optic flow, as we may expect the visual front end to do. 17. 2 Motion detection with pairs of receptive fields As a biologically motivated start, we begin with discussing some neurophysiological findings in the visual system with respect to motion detection.

Advances in semi-automated high-throughput image data collection routines, coupled with a decline in storage costs and an increase in high-performance computing solutions have led to an exponential surge in data collected by biomedical scientists and medical practitioners. Interpreting this raw data is a challenging task, and nowhere is this more evident than in the field of opthalmology. The sheer speed at which data on cataracts, diabetic retinopathy, glaucoma and other eye disorders are collected, makes it impossible for the human observer to directly monitor subtle, yet critical details. This book is a novel and well-timed endeavor to present, in an amalgamated format, computational image modeling methods as applied to various extrinsic scientific problems in ophthalmology. It is self-contained and presents a highly comprehensive array of image modeling algorithms and methodologies relevant to ophthalmologic problems. The book is the first of its kind, bringing eye imaging and multi-dimensional hyperspectral imaging and data fusion of the human eye, into focus. The editors are at the top of their fields and bring a strong multidisciplinary synergy to this visionary volume. Their "inverted-pyramid" approach in presenting the content, and focus on core applications, will appeal to students and practitioners in the field.

VipIMAGE 2015 contains invited lectures and full papers presented at VIPIMAGE 2015 - V ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing (Tenerife, Canary Islands, Spain, 19-21 October, 2015). International contributions from 19 countries provide a comprehensive coverage of the current state-of-the-art in the fields o

This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Successful thermal modeling of the human eye helps in the early diagnosis of eye abnormalities such as inflammation, cataracts, diabetic retinopathy, and glaucoma-all leading causes of blindness. This book presents a unified work of eye imaging and modeling techniques that have been proposed and applied to ophthalmologic problems. It delves into various morphological, texture, higher order spectra, and wavelet transformation techniques used to extract important diagnostic features from images, which can then be analyzed by a data scientist for automated diagnosis.