The combination of readily available computing power and progress in numerical techniques has made nonlinear systems - the kind that only a few years ago were ignored as too complex - open to analysis for the first time. Now realistic models of living systems incorporating the nonlinear variation and anisotropic nature of physical properties can be solved numerically on modern computers to give realistically usable results. This has opened up new and exciting possibilities for the fusing of ideas from physiology and engineering in the burgeoning new field that is biomechanics. Computational Biomechanics presents pioneering work focusing on the areas of orthopedic and circulatory mechanics, using experimental results to confirm or improve the relevant mathematical models and parameters. Together with two companion volumes, Biomechanics: Functional Adaptation and Remodeling and the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

In this volume, world authorities on spinal surgery from the fields of Neurosurgery, Orthopaedic Surgery, and Neuroscience present current data on the basic science and clinical management of the unstable spine. Unique to this book: a frank presentation of controversies in the field.

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

Biomechanics of the Female Pelvic Floor, Second Edition, is the first book to specifically focus on this key part of women's health, combining engineering and clinical expertise. This edited collection will help readers understand the risk factors for pelvic floor dysfunction, the mechanisms of childbirth related injury, and how to design intrapartum preventative strategies, optimal repair techniques, and prostheses. The authors have combined their expertise to create a thorough, comprehensive view of female pelvic floor biomechanics in order to help different disciplines discuss, research, and drive solutions to pressing problems. The book includes a common language for the design, conduct, and reporting of research studies in female PFD, and will be of interest to biomechanical and prosthetic tissue engineers and clinicians interested in female pelvic floor dysfunction, including urologists, urogynecologists, maternal fetal medicine specialists, and physical therapists. - Contains contributions from leading bioengineers and clinicians, and provides a cohesive multidisciplinary view of the field - Covers causes, risk factors, and optimal treatment for pelvic floor biomechanics - Combines anatomy, imaging, tissue characteristics, and computational modeling development in relation to pelvic floor biomechanics