Dr. Keshavarzian and Dr. Mutlu are well published in the area of complementary and alternative medicine (CAM) in the managmement of IBD are are considered top experts. They have assembled authority authors to present the latest clinical thinking on the use of CAM in IBD. Articles in this issue are devoted to: Use of CAM in IBD Around the World; Microbiota in IBD; Diet in IBD; Probiotics and IBD; Prebiotics and IBD; Fecal Transplant and IBD; Brain/Gut Axis, Stress and IBD; The Psychology of the IBD patient, and the Role of Lifestyle Modification and Hypnosis in Management; Role of Mindfulness and Cognitive Behavioral Therapy in IBD; Sleep and Circadian Hygiene and IBD; Herbs and IBD; Massage Acupuncture, Moxibustion and Other Forms of CAM in IBD; Exercise and IBD; Vitamins and Minerals in IBD; Dietary Therapies in Pediatric Inflammatory Bowel Disease: An Evolving IBD Paradigm; and Integrating CAM into Clinical practice in IBD: Pros and Cons. Readers should come away with sound clinical information that will aid them in the management of this disease.

This issue of Medical Clinics, guest edited by Dr. Robert Saper, is devoted to Complementary and Integrative Medicine. Articles in this outstanding issue address integrative medicine in the areas of mental health disorders; sleep disorders; neurological conditions; cardiovascular disease; respiratory disorders; gastrointestinal disorders; gynecological conditions; oncology; rheumatologic conditions; pain management; geriatric and palliative care; and physician health and wellbeing.

Dr. Loftus is a widely recognized expert in the diagnosis and treatment of Crohn's disease. He has created an issue devoted the current state-of-the-art on Crohn's disease; authors have written comprehensive reviews on the latest research to inform clinical diagnosis and treatment. Articles are devoted to the following topics: Genetics; Epidemiology, natural history, and risk stratification of Crohn’s disease; The microbiome in Crohn’s disease: Role in pathogenesis and role of microbiome replacement therapies; Endoscopic and radiographic assessment of Crohn’s disease; Intestinal and non-intestinal cancer risk in Crohn’s disease; Sexuality, fertility, and pregnancy in Crohn’s disease; Interdisciplinary management of perianal Crohn’s disease; Targeting specific immunologic pathways in human inflammatory bowel disease; Evolution of treatment paradigms in Crohn’s disease; Preventing and managing postoperative recurrence of Crohn’s disease; Where and how to use anti-TNF agents and anti-integrins in Crohn’s disease; Ustekinumab and anti-interleukin-23 agents in Crohn’s disease; Update on therapeutic drug monitoring in Crohn’s disease; and Janus kinase antagonists and other novel small molecules for the treatment of Crohn’s disease. Readers will come away from this issue armed with the information they need to improve management of this disease as well as patient outcomes.

In this issue of Gastroenterology Clinics, guest editor Dr. Sunanda V. Kane brings her considerable expertise to the topic of Medical and Surgical Management of Crohn's Disease. Approximately 3 million people worldwide suffer with Crohn's Disease, and this issue provides a thorough review of current treatment and management strategies in various patient populations. Topics include fecal microbiota transplant, microbiome-targeting diet, anti-TNF therapy in pediatric IBD patients, and many more. - Contains 13 practice-oriented topics including mimics of Crohn's; newer therapies for Crohn's disease; diet and nutrition in Crohn's disease; pediatric management of Crohn's disease; and more. - Provides in-depth clinical reviews of medical and surgical management of Crohn's disease, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

With collaboration of Consulting Editor, Dr. Alan Buchman, Guest Editors Drs. Gerard Mullen and Berkeley Limketkai have created a practical and current issue covering the breadth of topics in nutrition and gastrointestinal disease. Articles are specifically devoted to the following topics: Nutrition in the Management of Inflammatory Bowel Diseases; Irritable Bowel Syndrome: Food as a Friend or Foe; Treatment of Obesity: Beyond the Diet; Nutritional Management of Acute Pancreatitis; Nutritional Care in Patients with Intestinal Failure; The Life-long Role of Nutrition on the Gut Microbiome and Gastrointestinal Disease; Nutritional Strategies for Esophageal Disorders; Precision Medicine in Obesity; Gastrointestinal Food Allergies and Intolerances; All Things Gluten; Fish Oil for Inflammatory Bowel Disease: Panacea or Placebo; Nutrition Tools for the Practicing Gastroenterologist; Colorectal Cancer and Diet: Is Diet an Intervention; Non-Alcoholic Fatty Liver Disease: Nutritional Considerations; and Nutritional Considerations in the Hospital Setting. Readers will come away with current clinical information that they can employ in the clinical setting to improve outcomes in patients with gastrointestinal diseases.

This issue will be an informative treatise on gastroparesis, a symptomatic chronic disorder of the stomach characterized by delayed gastric emptying in the absence of mechanical obstruction. Gastroparesis is an increasingly recognized and diagnosed disorder. Treatment can be challenging due to several mechanisms which play a role in causing the symptoms. Symptoms of gastroparesis are variable and include early satiety, nausea, vomiting, bloating, and upper abdominal discomfort. These symptoms can range from mild to severe leading to such complications as malnutrition, functional disability, and multiple hospitalizations. The three most common etiologies are diabetes, post-surgical, and idiopathic (unknown). Treatment consists of dietary manipulation, medical, and surgical therapy. The articles will provide a comprehensive review and in-depth information on gastroparesis. Each chapter will be written by an expert in the area. This issue will give the reader a better appreciation for the breadth of gastroparesis.

Dr. Lefkowitch has created a primer on liver pathology for the gastroenterologist that provides depth of clinical coverage in an area not typically covered in depth for gastroenterologists. This issue will provide state-of-the-art reviews in the areas of NAFLD, liver biopsy, liver pathology, hepatitis, and genomics. Articles are specifically devoted to IgG4-related disease and the liver; current concepts in pediatric NAFLD; evaluation of the pediatric liver biopsy; hepatocellular adenomas: morphology and genomics; drug-induced liver injury: the hepatic pathologist’s approach; liver pathology in alpha-1-antitrypsin deficiency; immunohistochemistry in the diagnosis of hepatocellular carcinoma; HIV infection, antiretroviral therapy and liver pathology; autoimmune hepatitis overlap syndromes and liver pathology; current perspectives on the pathology of hepatocellular carcinoma and its variants; hepatitis E virus and the liver: clinical settings and liver pathology; hepatic progenitor cells; and cholangiocarcinoma: current genomics and pathology, to name a few.