This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

The potential benefits of plants and plant extracts in the treatment and possible prevention of many leading health concerns are historically well known and are becoming more widely studied and recognized within the medical community. It is these studies that led to the first compilation of new research developments, identifying new extracts and uses for plants in disease prevention and treatment. This major comprehensive reference work contains contributions from more than 150 clinical and academic experts covering topics such as treatments of cancer and cardiovascular diseases, as well as historical plant use by indigenous people supported by recent scientific studies. Authors review the safety and efficacy of botanical treatments while idenifying the sources, historical supportive data and mechanisms of action for emerging treatments. Written by researchers currently carrying out identification and biomedical testing, this is the most up to date text on the latest research from all over the world. It is an essential resource for health care practitioners and herbalists, as well as researcher, students and professionals in botany and alternative medicine.

Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.

When Someone You Love Has Advanced Cancer is a booklet for friends and family members taking care of a person with advanced cancer. This booklet covers making new decisions about care, how to discuss issues and changes with the health care team, getting support and asking for help, life planning and advance directives, talking with family and friends, talking with children and teens about advanced cancer, communicating with your loved one who has cancer, and tips on caring for both your physical and emotional self. Related products: Caring for the Caregiver: Support for Cancer Caregivers – ePub format only – ISBN: 9780160947520 Children with Cancer: A Guide for Parents -- ePub format only -- ISBN: 9780160947537 Coping with Advanced Cancer: Support for People with Cancer -- ePub format only ISBN: 9780160947544 Eating Hints: Before, during and after Cancer Treatment -- ePub format only --ISBN: 9780160947551 Life After Cancer Treatment: Facing Forward -- ePub format only -- ISBN: 9780160947568 Pain Control: Support for People with Cancer -- ePub format only -- ISBN: 9780160947575 Radiation Therapy and You: Support for People with Cancer --ePub format only -- ISBN: 9780160947582 Surgery Choice for Women with DCIS and Breast Cancer -- ePub format only -- ISBN: 9780160947599 Taking Part in Cancer Research Studies --ePub format only -- ISBN: 9780160947605 Understanding Breast Changes: A Health Guide for Women --ePub format only -- ISBN: 9780160947612 Understanding Cervical Changes: A Health Guide for Women -- ePub format only -- ISBN: 9780160947629 When Cancer Returns: Support for People with Cancer -- ePub format only -- ISBN: 9780160947636 When Someone You Love Has Completed Cancer Treatment: Facing Forward --ePub format only -- ISBN: 9780160947650 When Someone You Love Is Being Treated for Cancer: Support for Caregivers --ePub format only -- ISBN: 9780160947667 When Your Brother or Sister Has Cancer: A Guide for Teens --ePub format only -- ISBN: 9780160947674 When Your Parent Has Cancer: A Guide for Teens -- ePub format only -- ISBN: 9780160947681

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.