The series, Hematology reviews, focuses on key developments in Soviet fundamental and applied research, making recent medical advances in the USSR available to the researcher who does not read Russian. Topics reviewed in this volume include the biochemical and physiological mechanisms of blood clotting, the molecular and biological bases of hemostasis and the role played by prostaglandins in the regulation of blood clotting and fibrinolysis. Book club price, $31. Annotation copyrighted by Book News, Inc., Portland, OR

Hemopoiesis Regulation Mechanisms under Stress by Goldberg and Dygai describes recent results concerning the role of the neuroendocrine system and inter-cellular interactions in the regulation of hemopoiesis under stress. The authors also detail the role of the nervous and opioid systems, glucocorticoids, T-lymphocytes, phagocytic mononuclear cells and stromal mechanocytes in the regulation of the proliferation and differentiation of the various types of hemopoietic cells while the organism is under stress. Other articles discuss the hemostatic potential in various blood circulation departments, thrombohemorrhagic syndrome as a fundamental basis of general pathology, and effects of the gravisurgical correction of the aggregate state of blood on the functions of some organs and systems in case of ischemic heart disease. Among the five papers in this volume, RASB System and Hemopoiesis by O.K. Gavrilov characterizes the main types of RASB (Regulation of the Aggregate State of Blood

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.